Relationships and redundancies of selected hemodynamic and structural parameters for characterizing virtual treatment of cerebral aneurysms with flow diverter devices

Journal of Biomechanics
Christof KarmonikQinghai Huang

Abstract

To quantify the relationship and to demonstrate redundancies between hemodynamic and structural parameters before and after virtual treatment with a flow diverter device (FDD) in cerebral aneurysms. Steady computational fluid dynamics (CFD) simulations were performed for 10 cerebral aneurysms where FDD treatment with the SILK device was simulated by virtually reducing the porosity at the aneurysm ostium. Velocity and pressure values proximal and distal to and at the aneurysm ostium as well as inside the aneurysm were quantified. In addition, dome-to-neck ratios and size ratios were determined. Multiple correlation analysis (MCA) and hierarchical cluster analysis (HCA) were conducted to demonstrate dependencies between both structural and hemodynamic parameters. Velocities in the aneurysm were reduced by 0.14m/s on average and correlated significantly (p<0.05) with velocity values in the parent artery (average correlation coefficient: 0.70). Pressure changes in the aneurysm correlated significantly with pressure values in the parent artery and aneurysm (average correlation coefficient: 0.87). MCA found statistically significant correlations between velocity values and between pressure values, respectively. HCA sorted velocity pa...Continue Reading

References

May 12, 2005·Physiological Measurement·Matthew D FordDavid A Steinman
Apr 28, 2009·Journal of Biomechanics·Aishwarya R ManthaRalph W Metcalfe
Nov 3, 2010·Annals of Biomedical Engineering·Luca AugsburgerN Stergiopulos
Nov 26, 2010·Stroke; a Journal of Cerebral Circulation·Jianping XiangH Meng
Apr 19, 2012·Journal of Neurointerventional Surgery·Gregory A KuzmikKetan R Bulsara
May 5, 2012·AJNR. American Journal of Neuroradiology·Charles Strother, J Jiang
Nov 30, 2012·Computational and Mathematical Methods in Medicine·Jürgen EndresArnd Dörfler
Apr 30, 2013·Neurosurgery·Ignacio ArreseMiguel Delgado-Rodriguez
Aug 30, 2013·Journal of Neurointerventional Surgery·Koichiro TakemotoFernando Viñuela
Oct 17, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Santosh B MurthyJose I Suarez
Dec 21, 2013·AJNR. American Journal of Neuroradiology·R C PufferEdoardo Boccardi
Apr 12, 2014·AJNR. American Journal of Neuroradiology·Juan CebralDavid Kallmes
Nov 13, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sepideh Amin-HanjaniFady T Charbel

Related Concepts

Mycotic Aneurysm, Intracranial
In Silico
Hemodynamics
Stent, Device
Hydrodynamics
Aneurysm
Arteries
Statistical Cluster
Medical Devices
Silk Suture

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Adenoma, Liver Cell

Liver Cell Adenoma or hepatic adenoma is a rare benign tumor. It is associated with birth control use or pregnancy. Discover the latest research on Liver Cell Adenoma here.