Relationships between 25-hydroxyvitamin D levels and plasma glucose and lipid levels in pediatric outpatients

The Journal of Pediatrics
Michael D JohnsonSeema Kumar

Abstract

To study the relationships between serum vitamin D levels and plasma glucose or lipid levels in children and adolescents. We conducted a retrospective record review of pediatric outpatients (age, 2-18 years) with simultaneous measurement of 25-hydroxyvitamin D (25[OH] D) and fasting plasma glucose (n = 302) or 25(OH) D and a lipid panel (n = 177). Pearson correlation coefficient was used to estimate the correlation between 25(OH) D and logarithmic transformed plasma glucose or lipid levels. Plasma glucose and lipid levels were compared in subjects with 25(OH) D concentrations greater or less than 30 ng/mL. 25(OH) D levels were inversely correlated with fasting plasma glucose levels (r = -0.20, P < .001). Lower 25(OH) D levels were also associated with lower serum high-density lipoprotein cholesterol (HDL) concentrations (r = 0.41; P < or = .001). The relationship between 25(OH) D levels and fasting glucose and HDL levels did not vary significantly with sex, age, body mass index z-score, or season. Children who were vitamin D insufficient (25[OH] D < or =30 ng/mL) had higher fasting plasma glucose (P = .002) and lower HDL levels (P < .001) than children who were vitamin D sufficient (25[OH] D >30 ng/mL). Low 25(OH) D levels in c...Continue Reading

References

Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J AuwerxH Kesteloot
Jan 29, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ute ZeitzReinhold G Erben
Apr 29, 2004·The American Journal of Clinical Nutrition·Ken C ChiuMohammed F Saad
Jun 9, 2004·Archives of Pediatrics & Adolescent Medicine·Catherine M GordonS Jean Emans
Nov 25, 2004·Diabetes Care·Robert ScraggUNKNOWN Third National Health and Nutrition Examination Survey
Mar 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Bess Dawson-HughesReinhold Vieth
Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick
Apr 1, 2006·Clinical Chemistry·Gary L LensmeyerMarc K Drezner
Jul 11, 2006·The American Journal of Clinical Nutrition·Heike A Bischoff-FerrariBess Dawson-Hughes
Mar 29, 2007·The Journal of Clinical Endocrinology and Metabolism·Anastassios G PittasBess Dawson-Hughes
Jul 13, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·José I Botella-CarreteroHéctor F Escobar-Morreale
Sep 14, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Margarita Smotkin-TangorraSvetlana Ten
Jan 12, 2008·Nutrition·Kamilia TaiIan M Chapman
Jan 15, 2008·Metabolism: Clinical and Experimental·Ramin AlemzadehMariaelena Calhoun
May 29, 2008·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Jun 6, 2008·Archives of Pediatrics & Adolescent Medicine·Alisha J Rovner, Kimberly O O'Brien
Aug 12, 2008·The American Journal of Clinical Nutrition·Frank R Greer
Aug 12, 2008·The American Journal of Clinical Nutrition·Christel Je Lamberg-Allardt, Heli T Viljakainen
Dec 10, 2008·The American Journal of Clinical Nutrition·Anne C LookerElizabeth A Yetley
Mar 18, 2009·European Journal of Endocrinology·Marie-Hélène Gannagé-YaredGeorges Halaby

❮ Previous
Next ❯

Citations

Mar 4, 2011·The Journal of Clinical Endocrinology and Metabolism·Kumaravel RajakumarSilva A Arslanian
Dec 14, 2011·Journal of Clinical Research in Pediatric Endocrinology·Ajda MutluŞükrü Hatun
Oct 19, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J BacchettaP Cochat
Jul 12, 2011·Current Medical Research and Opinion·N KatsikiD P Mikhailidis
Nov 29, 2011·Nutrition Research·Sarada JaimungalMichael J Haas
Mar 1, 2011·Pediatric Diabetes·Zoya LagunovaJohan Moan
Jun 1, 2016·Diabetes Research and Clinical Practice·Sarah Al SawahTerri H Lipman
May 27, 2015·Pediatric Transplantation·Kirsten EbbertJanis Dionne
Oct 26, 2013·Osong Public Health and Research Perspectives·Han Byul JangJihyun Song
Oct 18, 2016·Critical Reviews in Food Science and Nutrition·Kelly Virecoulon GiudiciLígia Araújo Martini
Jun 7, 2016·Journal of Nutritional Science and Vitaminology·Zbigniew JastrzebskiJedrzej Antosiewicz
Oct 8, 2016·Iranian Journal of Pediatrics·Fatemeh TavakoliMahmood Zardast
Dec 5, 2017·The Proceedings of the Nutrition Society·Taryn J SmithKathryn H Hart
Feb 8, 2018·Journal of Endocrinological Investigation·M H Gannagé-YaredR Chédid
Feb 15, 2014·International Journal of Food Sciences and Nutrition·Roya KelishadiMaryam Bahreynian
Jun 9, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Anna S ChallaEkaterini C Siomou
Jul 16, 2015·PloS One·Catherine S BirkenUNKNOWN TARGet Kids! collaboration
Sep 23, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Swetha SriramSeema Kumar
May 24, 2017·Journal of Health, Population, and Nutrition·Sakineh Nouri SaeidlouZakaria Vahabzadeh
Apr 13, 2018·Metabolic Syndrome and Related Disorders·Md Jobayer HossainP Babu Balagopal
Apr 4, 2018·Annals of Pediatric Endocrinology & Metabolism·Ki Nam BaeKee-Hyoung Lee
Jan 23, 2013·Current Opinion in Cardiology·Jose A CanasPrabhakaran Babu Balagopal
Aug 1, 2021·Clinical Nutrition ESPEN·Aidah JuliatyJohan Setyawan Lisal

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.