Relationships between activated dendritic cells and dry eye symptoms and signs.

The Ocular Surface
Harry LevineAnat Galor

Abstract

To examine whether "activated" dendritic cells (aDCs) could serve as a biomarker of systemic immune disorders in individuals with dry eye (DE) symptoms. Secondarily, to examine the impact of a topical anti-inflammatory agent on aDC number. Retrospective analysis was conducted to identify individuals with DE symptoms who had in-vivo confocal microscopy (IVCM) imaging between October 2018 and July 2020 at the Miami Veterans Hospital. aDCs were manually quantified based on morphology. Receiver operating curve (ROC) analysis examined relationships between aDC number and systemic immune disease status. Individuals were then grouped by aDC number (≥2 versus <2) and demographics and DE parameters were examined. Paired t-test was performed to evaluated aDC number pre-vs post-initiation of an anti-inflammatory agent. 128 individuals were included. Their mean age was 57.1 ± 15.0 years; 71.1% were male, 53.1% self-identified as White and 24.2% as Hispanic. The mean number of aDCs in the central cornea was 1.28 ± 2.16 cells/image. The presence of ≥2 aDCs had a sensitivity of 60% and specificity of 77% for the diagnosis of a systemic immune disorder. Individuals with ≥2 aDCs were more likely to self-identify as Black, have Secondary Sjögren...Continue Reading

References

May 18, 2000·Archives of Ophthalmology·R M SchiffmanB L Reis
Mar 28, 2002·Cornea·Maria E RosenbergMinna H Vesaluoma
Jan 31, 2003·Investigative Ophthalmology & Visual Science·Pedram HamrahM Reza Dana
May 27, 2003·Investigative Ophthalmology & Visual Science·Ilpo S J TuominenTimo M T Tervo
Feb 27, 2004·Investigative Ophthalmology & Visual Science·M Reza Dana
Mar 20, 2004·Pain·Didier BouhassiraFrançois Boureau
Aug 25, 2004·Investigative Ophthalmology & Visual Science·José M Benítez del CastilloJulian Garcia-Sanchez
Oct 24, 2006·American Journal of Ophthalmology·Leonardo MastropasquaHarminder S Dua
Feb 24, 2007·American Journal of Ophthalmology·Biljana MiljanovićDebra A Schaumberg
Apr 27, 2007·Investigative Ophthalmology & Visual Science·Edoardo VillaniRoberto Ratiglia
Feb 1, 2008·Investigative Ophthalmology & Visual Science·Edoardo VillaniRoberto Ratiglia
Apr 12, 2008·Clinical Chemistry·Alyson Kelley-HedgepethUNKNOWN SWAN Investigators
Feb 13, 2009·American Journal of Ophthalmology·Anita GuptaEsen Karamursel Akpek
May 8, 2009·Cornea·Esen Karamursel AkpekAnn Ostrovsky
Jul 25, 2009·Investigative Ophthalmology & Visual Science·Hui LinZuguo Liu
Jan 23, 2010·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Robin L ChalmersBarbara Caffery
Mar 3, 2010·Immunological Reviews·John V ForresterPaul G McMenamin
Nov 27, 2010·Bosnian Journal of Basic Medical Sciences·Gordana ZlatanovićMarko Zlatanović
Apr 5, 2011·Investigative Ophthalmology & Visual Science·Andrea CruzatPedram Hamrah
Aug 23, 2011·Pain·Maria Alexandra Ferreira-ValenteMark P Jensen
Sep 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chris S SchaumburgMichael E Stern
Jan 11, 2012·Archives of Ophthalmology·William StevensonReza Dana
Mar 20, 2012·Progress in Retinal and Eye Research·Stefano BarabinoReza Dana
May 15, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Edoardo VillaniRoberto Ratiglia
May 28, 2013·Current Ophthalmology Reports·Miki Uchino, Debra A Schaumberg
Jun 14, 2013·Investigative Ophthalmology & Visual Science·Edoardo VillaniRoberto Ratiglia
Aug 21, 2013·Innate Immunity·László MarsovszkyAttila Balog
Sep 3, 2014·Ophthalmology·Esen Karamursel AkpekAlan N Baer
Oct 16, 2014·The Open Ophthalmology Journal·Federica MachettaFederico M Grignolo
Apr 22, 2015·Journal of Ophthalmology·Miklós D ReschAttila Balog
Apr 25, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Edoardo VillaniPaolo Nucci
Jul 4, 2015·Immune Network·Jaehak Oh, Jeoung-Sook Shin
Nov 6, 2015·Investigative Ophthalmology & Visual Science·Ahmad KheirkhahPedram Hamrah
Apr 12, 2016·The Journal of Clinical Investigation·Nan GaoFu-Shin Yu
May 21, 2016·BioMed Research International·Antonio M FeaFederico M Grignolo

❮ Previous
Next ❯

Citations

Jul 10, 2021·Clinical & Experimental Ophthalmology·Holly R ChinneryLaura E Downie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Stephanie BaahKhondaker Miraz Rahman
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Umbreen HafeezAndrew M Scott
Pharmacology & Therapeutics
Yiming JinAndrew J Wiemer
American Society of Clinical Oncology Educational Book
Rohan Mathur, George J Weiner
© 2021 Meta ULC. All rights reserved