Relationships between amyloid levels, glucose metabolism, morphologic changes in the brain and clinical status of patients with Alzheimer's disease

Annals of Nuclear Medicine
Tanyaluck ThientunyakitJuri G Gelovani

Abstract

The current study was conducted to improve the understanding of relationships between regional cortical amyloid load, glucose metabolism, cortical morphology (volume), and severity of clinical symptoms in patients with AD, MCI, and age-matched controls. To objectivize the radiological evaluation of patients with suspected AD, head-to-head multi-modality imaging studies were conducted using MRI and PET/CT with [18F]FDG and [18F]AV45 for visualization and quantitation of brain morphology, glucose metabolism, and amyloid levels, respectively. A total of 84 subjects was studied, including 33 patients with AD, 31 patients with MCI, and 20 age-matched healthy controls (HC). A new quantitative index was calculated as a ratio of regional SUV of [18F]AV45 (normalized to cerebellar cortex) over the corresponding regional SUV of [18F]FDG, divided by the corresponding regional volume, measured from the co-registered MRI and normalized to the normal age-matched control group (AV45/FDG/NVol index). Relationships between clinical scores (TMSE, ADAS) and AV45/FDG/NVol indices for different structures of the brain in study groups were determined using linear regression analyses. A significant direct linear correlation was observed between the A...Continue Reading

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Citations

Mar 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Damiano LibrizziBehrooz Hooshyar Yousefi
May 22, 2021·Japanese Journal of Radiology·Tanyaluck ThientunyakitKazunari Ishii
Sep 6, 2020·Progress in Retinal and Eye Research·Veer B GuptaVivek Gupta

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