Relationships between block-of-twitch and train-of-four fade in the mouse phrenic nerve-diaphragm preparation

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
R J StorellaH Rosenberg


The relationships between the block-of-twitch and train-of-four fade in the presence of nondepolarizing neuromuscular blocking drugs (d-tubocurarine, vecuronium and pancuronium) were examined in vitro by measuring the contractile tension from mouse phrenic nerve-diaphragm preparations. The slope of the block/fade relationship differed between onset of and recovery from neuromuscular block following single doses of d-tubocurarine, vecuronium or pancuronium. Decreasing the dose of d-tubocurarine or using a divided dose technique to accelerate onset (i.e., priming) increased the amount of fade for a given amount of block. In addition, the block/fade relationships for cumulative dosing and sequential dilution were the same when measurements were made at steady-state for several doses. It is concluded that the block/fade relationship in the mouse phrenic nerve-diaphragm preparation is variable, and is related to the time course of the neuromuscular block. In addition, the block/fade relationships for d-tubocurarine, vecuronium and pancuronium did not differ when determined at steady-state.


Aug 1, 1976·Anesthesiology·H H Ali, J J Savarese
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Dec 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H ShiraishiS Ogawa
Feb 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R J Storella, T S Ackerman
Oct 14, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H ItohT Kobayashi
Mar 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·R J StorellaL A Smith

Related Concepts

Respiratory Diaphragm
Potentials, Event-Related
Pancuronium Curamed
Structure of Phrenic Nerve
Reaction Time
Cholinergic Receptors
Tubocurarine Chloride

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