Relationships between density and Young's modulus with microporosity and physico-chemical properties of Wistar rat cortical bone from growth to senescence

Medical Engineering & Physics
M VanleeneM C Ho Ba Tho

Abstract

The aim of this study is to assess density and elastic properties of Wistar rat cortical bone from growth to senescence and to correlate them with morphological and physico-chemical properties of bone. During growth (from 1 to 9 months), bone density and Young's modulus were found to increase from 1659+/-85 to 2083+/-13 kg m(-3) and from 8+/-0.8 to 19.6+/-0.7 GPa respectively. Bone microporosity was found to decrease from 8.1+/-0.7% to 3.3+/-0.7%. Physico-chemical investigations exhibited a mineralization of bone matrix and a maturation of apatite crystals, as protein content decreased from 21.4+/-0.2% to 17.6+/-0.6% and apatite crystal size and carbonate content increased (c-axis length: from 151 to 173 A and CO(3)W%: from 4.1+/-0.3% to 6.1+/-0.2%). At adult age, all properties stabilized. During senescence, a slow decrease of mechanical properties was first observed (from 12 to 18 months, rho=2089+/-14 to 2042+/-30 kg m(-3) and E(3)=19.8 +/-1.3 to 14.8+/-1.5 GPa), followed by a stabilization. Physico-chemical properties stabilized while microporosity increased slightly (from 3.3% to 4%) but not significantly (p>0.05). A multiple regression analysis showed that morphological and physico-chemical properties had significant effe...Continue Reading

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Citations

Sep 10, 2011·Medical Engineering & Physics·Yunkai LuMark L Johnson
Jul 31, 2014·Computer Methods in Biomechanics and Biomedical Engineering·S Jaramillo-IsazaM-C Ho Ba Tho
Jul 31, 2020·Journal of the American College of Nutrition·Marcella Duarte Villas MishimaHércia Stampini Duarte Martino
Oct 19, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S YangL M Lix
Jan 16, 2020·Medical & Biological Engineering & Computing·S H HuoG R Liu
Mar 16, 2021·Journal of the Mechanical Behavior of Biomedical Materials·S H HuoR H Ao

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