Relationships between emm and multilocus sequence types within a global collection of Streptococcus pyogenes.

BMC Microbiology
Debra E BessenAdrian M Whatmore

Abstract

The M type-specific surface protein antigens encoded by the 5' end of emm genes are targets of protective host immunity and attractive vaccine candidates against infection by Streptococcus pyogenes, a global human pathogen. A history of genetic change in emm was evaluated for a worldwide collection of > 500 S. pyogenes isolates that were defined for genetic background by multilocus sequence typing of housekeeping genes. Organisms were categorized by genotypes that roughly correspond to throat specialists, skin specialists, and generalists often recovered from infections at either tissue site. Recovery of distant clones sharing the same emm type was approximately 4-fold higher for skin specialists and generalists, as compared to throat specialists. Importantly, emm type was often a poor marker for clone. Recovery of clones that underwent recombinational replacement with a new emm type was most evident for the throat and skin specialists. The average ratio of nonsynonymous substitutions per nonsynonymous site (Ka) and synonymous substitutions per synonymous site (Ks) was 4.9, 1.5 and 1.3 for emm types of the throat specialist, skin specialist and generalist groups, respectively. Data indicate that the relationships between emm ty...Continue Reading

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Citations

Sep 26, 2009·The Lancet Infectious Diseases·Andrew C SteerJonathan R Carapetis
Sep 29, 2011·Journal of Bacteriology·Debra E BessenHervé Tettelin
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Dec 3, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Debra E BessenHervé Tettelin
Mar 6, 2012·The American Journal of Pathology·Debra E Bessen
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Sep 8, 2018·Microbiology Spectrum·Debra E BessenBernard W Beall
Nov 5, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Magnus G JespersenMark R Davies

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Clustal W
Megalign
DnaSP
eBURST
Clustal
emm96

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