Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines

Leukemia Research
Daiane S MarquesGilma Santos Trindade

Abstract

The K562 cell line (chronic myeloid leukemia), sensitive to chemotherapy (non-MDR), and the Lucena cell line, resistant to chemotherapy (MDR) were investigated. The results suggest that both cell lines possess CD34+CD38- profiles of hematopoietic stem cell markers. The promoter regions of ABCB1, ABCG2 and ABCC1 genes contain binding sites for the Oct-4 transcripton factor, which is also considered a marker of tumor stem cells. Lucena cells showed an over-expression of the ABCB1 gene and a high expression of the Oct-4, ABCG2 and ABCC1 genes as compared to K562 cells.

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Citations

Jul 6, 2014·Leukemia Research·Miguel Angelo Martins MoreiraVivian Mary Rumjanek
Feb 8, 2016·Leukemia Research·Michele Carrett-DiasGilma Santos Trindade
Nov 16, 2010·Gene Expression Patterns : GEP·Liwen LiHan-Sung Jung
Apr 19, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Asmaa Gaber AbdouNoha Elkady
Jan 12, 2010·Leukemia Research·Amit K TiwariZhe-Sheng Chen
May 6, 2016·Frontiers in Oncology·Maria Grazia CipolleschiPersio Dello Sbarba
Nov 2, 2013·World Journal of Stem Cells·Jiabo DiRuurd Torensma
Jan 15, 2018·Pharmacological Reports : PR·Estela Fernandes E SilvaAna Paula de Souza Votto
Nov 4, 2016·Clinical and Experimental Pharmacology & Physiology·Jennifer Petra SchöningWenyi Gu
Oct 31, 2014·Molecular and Cellular Biochemistry·Bruno Rodrigues OliveiraLuis Fernando Marins

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