PMID: 6162906Feb 1, 1981Paper

Relationships between oestradiol-17 beta, testosterone, dihydrotestosterone and 5 alpha-androstane-3 alpha, 27 beta-diol in human benign hypertrophy and carcinoma of the prostate

The Journal of Endocrinology
R Ghanadian, C M Puah

Abstract

The relationship between the concentrations of oestradiol, testosterone, dihydrotestosterone (DHT) and 5 alpha-androstane-3 alpha, 17 beta-diol in circulating blood and prostatic tissues was studied in patients with benign prostatic hypertrophy (BPH) and carcinoma of the prostate. All steroids were measured by radioimmunoassay. In patients with BPH the tissue concentrations of oestradiol, testosterone, DHT and 5 alpha-androstane-3 alpha, 17 beta-diol expressed per kg wet weight were 228.6 +/- 7.4 (S.E.M.) pmol, 1.29 +/- 0.06 nmol, 25.61 +/- 1.15 nmol and 1.43 +/- 0.10 nmol respectively. The corresponding values for carcinomatous tissues were 380.1 +/- 19.4 pmol, 7.20 +/- 1.10 nmol, 12.32 +/- 1.56 nmol and 1.99 +/- 0.32 nmol. Significant differences (t-test) were found between the mean concentrations of oestradiol (P less than 0.001), testosterone (P less than 0.001), DHT (P less than 0.001) and 5 alpha androstane-3 alpha, 17 beta-diol (P less than 0.05) in prostatic tissues of these two groups of patients. Significant negative correlations were observed between the tissue concentrations of oestradiol and DHT (r = -0.49, P less than 0.05) and between oestradiol and 5 alpha-androstane-3 alpha,17 beta-diol (r = -0.44, P less than ...Continue Reading

Citations

Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Davaasambuu GanmaaAkio Sato
Jul 1, 1982·Journal of Steroid Biochemistry·T SmithF K Habib
Jan 1, 1987·Journal of Steroid Biochemistry·W BartschK D Voigt
Nov 1, 1992·British Journal of Urology·E D Crawford
Jan 14, 2011·Nature Reviews. Urology·Clement K M Ho, Fouad K Habib
Feb 1, 1991·The Journal of Urology·A W PartinP C Walsh
Jul 1, 1988·The Journal of Urology·D N Osegbe, J O Ogunlewe
Aug 7, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ken-Ichi OhnoKouwa Yamashita
Jan 1, 1990·The Journal of International Medical Research·A V BonoP Preti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.