Relationships between peak force, action potential duration and stimulus interval in rabbit myocardium

Acta Physiologica Scandinavica
Bjorn Wohlfart


Isometric force and membrane action potential were recorded simultaneously in rabbit papillary muscles (36.5 degrees--37.5 degrees C). One to three test stimuli were given at various intervals (0.20--10.0 s) after a series of control contractions at constant stimulation intervals (1.0--1.5 s). Optimum peak force always occurred when the preceding test interval was 0.80 s. When this interval was greater than 0.80 s, time to peak force was a linear function of the action potential duration. Furthermore, under these conditions the action potential duration (AP1) and peak force (F1) of the test contraction could be used to predict peak force (F2) of the subsequent contraction elicited after a fixed interval (0.80--1.50 s) according to the equation (regression plane): F2 = BAPAP1 + BFF1 + A. Constants BAP and BF are interpreted to provide information about calcium influx during the action potential and of the recirculation of calcium between contractions, respectively. F2 deviated towards higher values than predicted from the equation when the preceding test contraction was triggered to occur at an interval less than 0.80 s. This may be due to an intensified calcium transport into the cell during the action potential after these sho...Continue Reading


Nov 1, 1984·Pflügers Archiv : European journal of physiology·C PoggesiS Testa
Oct 1, 1983·Pflügers Archiv : European journal of physiology·N I KukushkinE A Sosunov
Jan 1, 1994·Heart and Vessels·J ArakiH Suga
Sep 1, 1983·Basic Research in Cardiology·J M CapassoE H Sonnenblick
Nov 1, 1990·Basic Research in Cardiology·V J SchoutenG P Swier
Sep 1, 1990·Medical & Biological Engineering & Computing·R BeyarS Sideman
Feb 19, 1982·European Journal of Pharmacology·S HaradaT Ban
Jan 1, 1982·Pharmacology & Therapeutics·Bjorn Wohlfart, M I Noble
Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·Z J PenefskyA L Sorensen
Jan 1, 1986·Journal of the American College of Cardiology·Y NakamuraC Kawai
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Toshiaki SumidaShigefumi Morioka
Apr 1, 1990·Australian and New Zealand Journal of Medicine·Y SugishitaG Reddacliff
Mar 4, 2003·Journal of Cellular and Molecular Medicine·J S Juggi
Nov 1, 1980·Acta Physiologica Scandinavica·M Jóhannsson, Bjorn Wohlfart
Feb 1, 1981·Acta Physiologica Scandinavica·A R Khan, Bjorn Wohlfart
Jun 1, 1982·Acta Physiologica Scandinavica·K RagnarsdóttirM Jóhannsson
Aug 1, 1982·Acta Physiologica Scandinavica·Bjorn Wohlfart
Jun 1, 1987·Acta Physiologica Scandinavica·Bjorn Wohlfart, A R Khan
Feb 1, 1989·Acta Physiologica Scandinavica·M Jóhannsson, H Asgrímsson
Aug 1, 1990·Acta Physiologica Scandinavica·S E Mörner, Bjorn Wohlfart
Sep 1, 1990·Acta Physiologica Scandinavica·P Arlock, Bjorn Wohlfart
Jun 1, 1991·Acta Physiologica Scandinavica·S E Mörner, Bjorn Wohlfart
Feb 1, 1995·Acta Physiologica Scandinavica·H AsgrímssonS A Arnardóttir
Jan 1, 1992·British Heart Journal·J M MorganE Rowland
May 10, 2001·Journal of Molecular and Cellular Cardiology·G Y OuditP H Backx
Sep 1, 2012·Journal of Echocardiography·Kazuto YamaguchiKazuaki Tanabe
Oct 6, 2005·European Journal of Heart Failure·Corinna B BrunckhorstDaniel Burkhoff
May 1, 1987·Catheterization and Cardiovascular Diagnosis·R IliaM Gueron
Nov 1, 2005·Journal of Biomechanics·Mark I M NobleAngela J Drake-Holland
Jul 28, 2016·PLoS Computational Biology·Joshua MayourianKevin D Costa


Jan 1, 1977·Annual Review of Physiology·H A Fozzard
Dec 1, 1976·Japanese Circulation Journal·M Hiraoka, T Sano
Feb 1, 1976·Journal of Molecular and Cellular Cardiology·T W Anderson, E A JOHNSON
Jun 1, 1975·The American Journal of Physiology·B G Bass
Jan 1, 1976·The Journal of Physiology·D G AllenE H Wood
Jan 1, 1976·The Journal of Physiology·K A Edman, M Jóhannsson
Jan 1, 1970·Pflügers Archiv : European journal of physiology·P Bravený, J Sumbera
Jan 1, 1972·Pflügers Archiv : European journal of physiology·W New, W Trautwein
Apr 1, 1956·The American Journal of Physiology·B F HOFFMANE E SUCKLING

Related Concepts

Myocardial Contraction
Structure of Papillary Muscle
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