Relationships between Physiologic and Neuropsychologic Functioning after Fontan.

The Journal of Pediatrics
Kelly WolfeMichael V Di Maria

Abstract

To investigate potential relationships between neuropsychologic functioning and cardiac, gastroenterologic/hepatologic, and pulmonary complications in the single ventricle heart disease (SVHD) post-Fontan population. Following the initiation of a Fontan Multidisciplinary Clinic, patients with SVHD were evaluated systematically according to a clinical care pathway, and data from multiple subspecialty evaluations were collected prospectively from 2016 to 2019. Biomarkers of cardiology, pulmonary, and hepatology/gastroenterology functioning were abstracted, along with neuropsychologic testing results. Bivariate correlations and regression analyses examined cross-sectional relationships between physiologic predictors and neuropsychologic outcomes. The sample included a cohort of 68 youth with SVHD age 3-19 years, after Fontan palliation. Sleep-disordered breathing was related to poorer visual-motor integration skills (r = -0.33; P < .05) and marginally related to poorer executive functioning (r = -0.33; P = .05). Lower arterial blood oxygen content was related to poorer executive functioning (r = .45; P < .05). Greater atrioventricular valve regurgitation was related to lower parent-rated adaptive functioning (ρ = -0.34; P < .01). ...Continue Reading

Citations

Nov 23, 2020·Journal of Clinical Psychology in Medical Settings·Rachel E SicilianoLori C Jordan
Aug 10, 2021·Current Opinion in Pediatrics·Joseph BurnsArushi Dhar
Nov 9, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Kelly R WolfeGreta Wilkening

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