Relationships between plasma lipidomic profiles and brown adipose tissue density in humans.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Sayuri FuseTakafumi Hamaoka

Abstract

The thermogenic function of brown adipose tissue (BAT) is generally activated in winter and tightly regulated through various metabolic processes. However, the mechanisms mediating these changes have not been elucidated in humans. Here, we investigated the relationships between BAT density (BAT-d) and lipid metabolites in plasma from men and women in the winter and summer. In total, 92 plasma samples were obtained from 23 men and 23 women, aged 21-55 years, on two different occasions (summer and winter). Lipid metabolites were comprehensively quantified using liquid chromatography-time-of-flight-mass spectrometry. BAT-d was evaluated by measuring total hemoglobin concentrations in the supraclavicular region using near-infrared time-resolved spectroscopy. Anthropometric parameters, such as the percentage of whole body fat and visceral fat area (VFA), were evaluated. Factors influencing BAT-d were investigated by univariate and multivariate regression analyses. A variety of metabolite peaks, such as glycerophospholipids (168 peaks), steroids and derivatives (78 peaks), fatty acyls (62 peaks), and glycerolipids (31 peaks), were detected. Univariate regression analysis, corrected by false discovery rate to yield Q values, revealed ...Continue Reading

References

Jul 11, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J LeBlancD Richard
Apr 20, 2001·Advanced Drug Delivery Reviews·I M Hafez, P R Cullis
Mar 5, 2003·BioTechniques·A I SaeedJ Quackenbush
Mar 28, 2003·Biochemical and Biophysical Research Communications·Je-Won RyuKi-Up Lee
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
May 13, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Toshihiko YanaseHajime Nawata
Apr 10, 2009·The New England Journal of Medicine·Wouter D van Marken LichtenbeltG J Jaap Teule
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Mar 23, 2012·Current Bioinformatics·Masahiro SugimotoMasaru Tomita
May 2, 2012·Endocrinology·Oleg VarlamovCharles T Roberts
Oct 4, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T YoneshiroM Saito
Jul 23, 2013·The Journal of Clinical Investigation·Takeshi YoneshiroMasayuki Saito
Nov 12, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M MatsushitaM Saito
Nov 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Kirill TarasovWinfried März
Feb 18, 2014·Methods in Enzymology·Rodney C BakerAngela R Subauste
Nov 18, 2014·Biomedical Optics Express·Sonny GunadiIlias Tachtsidis
Aug 10, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Aidan FlynnMarielle Scherrer-Crosbie
Jan 1, 2016·Diabetes·Mark J W HanssenWouter D van Marken Lichtenbelt
Nov 4, 2016·Medical Oncology·Jaroslav TumasAudrius Sileikis
Mar 21, 2017·Metabolomics : Official Journal of the Metabolomic Society·Mariëtte R BoonDennis O Mook-Kanamori
Feb 23, 2018·Journal of Physiological Anthropology·Shinsuke NirengiTakafumi Hamaoka
Oct 18, 2018·Nature Chemical Biology·Martina WallaceChristian M Metallo
Aug 23, 2019·Nature·Takeshi YoneshiroShingo Kajimura

❮ Previous
Next ❯

Citations

Jun 9, 2020·Frontiers in Endocrinology·Takafumi HamaokaYuko Kurosawa
Dec 10, 2020·Journal of Clinical Medicine·Hiroyuki ShimizuHiroshi Goto
Jan 14, 2021·Investigative Ophthalmology & Visual Science·Hiroyuki ShimizuHiroshi Goto
Mar 7, 2021·Metabolites·Helaina Von BankJudith Simcox
May 8, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elisa Félix-SorianoMaría J Moreno-Aliaga
Jun 3, 2021·Journal of Clinical Medicine·Miyuki KuroiwaTakafumi Hamaoka

❮ Previous
Next ❯

Methods Mentioned

BETA
metabolomic profiling

Software Mentioned

MassHunter
MassHunter Qualitative Analysis
SPSS
GraphPad Prism
Agilent MassHunter Qualtative Analysis

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.