Relationships between polyamine metabolism and RNA synthesis in post-ischemic liver cell repair

Journal of Cellular Physiology
M E FerioliA Bernelli-Zazzera

Abstract

In liver cells recovering from reversible ischemia the increase in RNA synthesis by isolated nuclei is preceded by activation of ornithine decarboxylase, leading in turn to an increase in putrescine concentration. Treatment of the animals with 1,3-diaminopropane and putrescine prevents ornithine decarboxylase activation but does not hinder the enhancement of RNA synthesis in post-ischemic liver nuclei; therefore, ornithine decarboxylase activation does not seem to be a necessary prerequisite for the increase in RNA synthesis. Hypophysectomy does not prevent the post-ischemic increases of ornithine decarboxylase and RNA synthesis; but pre-treatment of the animals with cycloheximide--which has a dual effect on the activity of ornithine decarboxylase--abolishes the post-ischemic enhancement of RNA synthesis. In contrast with regenerating liver, changes in ornithine decarboxylase activity and putrescine concentrations in reversible ischemia are not associated to changes in S-adenosylmethionine decarboxylase activity and in spermine and spermidine concentrations that seem to be characteristic of tissues where increases in RNA synthesis are followed by DNA synthesis and cell multiplication.

References

Dec 1, 1978·Journal of Cellular Physiology·L SchiaffonatiA Bernelli-Zazzera
Jan 1, 1979·Biochemical Pharmacology·D V Maudsley
Feb 27, 1979·Biochimica Et Biophysica Acta·H T AbelsonC D Scher
Apr 14, 1978·Biochemical and Biophysical Research Communications·P J Dehlinger, M Litt
Dec 15, 1977·Biochemical Pharmacology·C A Manen, D H Russell
Oct 16, 1978·Life Sciences·R Wondergem, V R Potter
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R H FillingameD R Morris
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P S MamontC Tardif
Jul 1, 1975·Experimental Cell Research·I DaskalH Busch
Apr 19, 1976·Biochemical and Biophysical Research Communications·H Pöso, J Jänne
Jun 28, 1972·Journal of Molecular Biology·R H Reeder, R G Roeder
Oct 1, 1972·Analytical Biochemistry·P J Geiger, S P Bessman
Apr 2, 1973·Biochemical and Biophysical Research Communications·J L Farber, R Farmar
Aug 28, 1973·Biochemistry·W F MarzluffR C Huang
Sep 5, 1973·Biochemical and Biophysical Research Communications·B BarbiroliB Tadolini
Nov 26, 1973·Biochimica Et Biophysica Acta·M T Franze-Fernańdez, A V Fontanive-Sengüesa
Feb 1, 1974·Experimental and Molecular Pathology·L Zardi, R Baserga
Jun 1, 1971·Experimental and Molecular Pathology·F CajoneM Bassi
Oct 14, 1970·Journal of Molecular Biology·M MuramatsuT Higashinakagawa
Aug 1, 1964·Experimental and Molecular Pathology·A BERNELLI-ZAZZERA, G GAJA

❮ Previous
Next ❯

Citations

Jan 1, 1980·The International Journal of Biochemistry·F Cajone, A Bernelli-Zazzera
Jan 1, 1989·Journal of the Neurological Sciences·E C LorenziniN Canal
Jun 1, 1992·Experimental and Molecular Pathology·R PiccolettiA Bernelli-Zazzera
Feb 1, 1985·Journal of Neurochemistry·G A DienelS J Rosenfeld
Apr 1, 1990·Journal of Cellular Physiology·L SchiaffonatiA Bernelli-Zazzera
Jan 1, 1989·Free Radical Research Communications·A Bernelli-Zazzera
Oct 1, 1982·Molecular and Cellular Biochemistry·L SchiaffonatiA Bernelli-Zazzera

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
M Takamori
Journal of Cellular Physiology
L SchiaffonatiA Bernelli-Zazzera
Experimental and Molecular Pathology
H M Lazarus, A Hopfenbeck
© 2021 Meta ULC. All rights reserved