Relationships between reported macronutrient intake and insulin dynamics in a multi-ethnic cohort of early pubertal children.

International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity
Krista CasazzaJose R Fernandez

Abstract

Racial/ethnic differences in the pediatric population in insulin dynamics have been documented. Additionally, girls tend to be more insulin resistant than boys. Although the mechanism driving these differences is unclear, diet may be a contributor. The objective of this study was to evaluate the contribution of reported macronutrient intake on insulin dynamics and determine if diet composition may account for racial/ethnic and sex differences in insulin response/action. Participants were 250 African- (n=84), European- (n=105), or Hispanic-American (n=61) children 7-12 years, pubertal stage < or =3. An intravenous glucose tolerance test was used to derive the insulin sensitivity index and acute insulin response to glucose (AIRg) diet by two 24 h recalls, and body composition by dual-energy x-ray absorptiometry (DXA). Reported energy intake from fat was positively related to fasting insulin (P < 0.05) and AIRg (P=0.05). Reported energy from carbohydrate was inversely associated with fasting insulin (P < 0.05), and reported energy from protein was inversely associated with AIRg (P < 0.05). The interaction terms between ethnicity and diet, and sex and diet were not significant for any outcome variables. Dietary intake influences in...Continue Reading

Citations

Nov 10, 2011·Journal of Pediatric Gastroenterology and Nutrition·Krista CasazzaStephenie Wallace
Jan 27, 2015·The British Journal of Nutrition·Trudy VoortmanEdith H van den Hooven
Oct 9, 2014·Current Treatment Options in Cardiovascular Medicine·Mandy HoLouise A Baur
Apr 18, 2020·The Journal of Clinical Endocrinology and Metabolism·Jasmin M AlvesKathleen A Page

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