Relationships between serum concentrations of C-reactive protein and micronutrients, in patients with tuberculosis

Annals of Tropical Medicine and Parasitology
A KoyanagiL E Cuevas

Abstract

Studies on the serum concentrations of micronutrients in tuberculosis (TB), and their relationship to the acute-phase response (APR), are scarce. The serum concentrations of zinc, copper, selenium and vitamins A and E in 46 smear-positive cases of pulmonary TB (PTB) from Ecuador were therefore compared with those in 10 healthy Ecuadorian volunteers, and the correlations between these concentrations and the serum concentration of C-reactive protein (CRP) were evaluated. Compared with the healthy volunteers, the PTB cases had significantly lower serum concentrations of zinc, retinol and selenium and significantly higher serum concentrations of copper. Both groups had moderately high concentrations of selenium in their sera. The PTB cases who had >50 mg CRP/ litre (a concentration indicative of an APR) had lower serum concentrations of retinol and zinc than the cases with lower CRP concentrations. In patients with PTB, hypozincaemia and hyporetinolaemia are strongly associated with the APR. It is therefore necessary to consider the extent of activation of the APR when interpreting serum micronutrient concentrations in patients with TB.

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Citations

Feb 13, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Maria Luiza Doria AlmeidaLuis Eduardo Cuevas
Dec 13, 2005·European Journal of Clinical Nutrition·A KassuF Ota
Oct 8, 2009·The Journal of Biological Chemistry·Carine WhiteMichael J Petris
Apr 23, 2008·Journal of Cardiovascular Pharmacology·Yelena SelektorKarl T Weber
Sep 15, 2005·Annals of Tropical Paediatrics·Luis E Cuevas, Ai Koyanagi
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Surya KantSavita Ahluwalia
Nov 29, 2016·Indian Journal of Sexually Transmitted Diseases and AIDS·Arun VishwanathRuhi Khan
Feb 6, 2015·Metallomics : Integrated Biometal Science·Erik Ladomersky, Michael J Petris
Aug 31, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·César CárcamoKing K Holmes
Mar 6, 2012·The Journal of Biological Chemistry·Victoria Hodgkinson, Michael J Petris
Feb 8, 2007·The American Journal of Clinical Nutrition·Paul K DrainWafaie W Fawzi
Jun 1, 2018·American Journal of Respiratory Cell and Molecular Biology·Michelle M ColemanJoseph Keane
Jun 12, 2021·Frontiers in Immunology·Tamiris Lameira BittencourtRoberta Olmo Pinheiro

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