Abstract
To examine the relationship between sleep duration and hemostatic factors in a well-characterized cohort. The relationship between self-reported sleep duration and von Willebrand factor (vWF), fibrinogen, and factor VII was examined in approximately 6400 individuals from the Whitehall II Study. The analysis was stratified by sex (interaction P<0.001). After multiple adjustments, vWF levels were significantly higher in men with both short sleep duration (≤6 hours per night; 1.05 [95% CI, 1.01 to 1.08] [data given as geometric mean]) and long sleep duration (≥8 hours per night; 1.05 [95% CI, 1.02 to 1.08]) compared with those who slept 7 hours (P<0.05 for both). In women, levels of vWF were significantly higher in individuals who slept 8 hours or longer (1.11 [95% CI, 1.06 to 1.16]) compared with 7 hours (P<0.05). This difference was observed in premenopausal and postmenopausal women. In women, the association was nonlinear (P=0.02), but not in men (P=0.09). No statistically significant associations between sleep duration and fibrinogen or factor VII were observed. Men who slept for short and long durations had higher vWF levels. In women, there was a significant nonlinear association. The highest levels were observed in long sle...Continue Reading
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