Relationships between sleep duration and von Willebrand factor, factor VII, and fibrinogen: Whitehall II study.

Arteriosclerosis, Thrombosis, and Vascular Biology
Michelle A MillerFrancesco P Cappuccio

Abstract

To examine the relationship between sleep duration and hemostatic factors in a well-characterized cohort. The relationship between self-reported sleep duration and von Willebrand factor (vWF), fibrinogen, and factor VII was examined in approximately 6400 individuals from the Whitehall II Study. The analysis was stratified by sex (interaction P<0.001). After multiple adjustments, vWF levels were significantly higher in men with both short sleep duration (≤6 hours per night; 1.05 [95% CI, 1.01 to 1.08] [data given as geometric mean]) and long sleep duration (≥8 hours per night; 1.05 [95% CI, 1.02 to 1.08]) compared with those who slept 7 hours (P<0.05 for both). In women, levels of vWF were significantly higher in individuals who slept 8 hours or longer (1.11 [95% CI, 1.06 to 1.16]) compared with 7 hours (P<0.05). This difference was observed in premenopausal and postmenopausal women. In women, the association was nonlinear (P=0.02), but not in men (P=0.09). No statistically significant associations between sleep duration and fibrinogen or factor VII were observed. Men who slept for short and long durations had higher vWF levels. In women, there was a significant nonlinear association. The highest levels were observed in long sle...Continue Reading

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Citations

Apr 19, 2013·Journal of Human Hypertension·M A Miller, F P Cappuccio
Dec 14, 2012·PloS One·Linn B StrandImre Janszky
Oct 19, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Michelle A Miller
Jul 31, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Paul A RobersonChristopher J Womack
Nov 10, 2018·Nature Reviews. Cardiology·Eleonora TobaldiniNicola Montano
Jan 25, 2012·Annals of Neurology·Martin BlachierJean-Philippe Empana
Mar 14, 2021·European Journal of Epidemiology·Shuai YuanSusanna C Larsson
Jun 30, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V V GafarovA V Gafarova

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