Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
David B BerryLawrence R Frank

Abstract

To establish a series of relationships defining how muscle microstructure and diffusion tensor imaging (DTI) are related. The relationship among key microstructural features of skeletal muscle (fiber size, fibrosis, edema, and permeability) and the diffusion tensor were systematically simulated over physiologically relevant dimensions individually, and in combination, using a numerical simulation application. Stepwise multiple regression was used to identify which microstructural features of muscle significantly predict the diffusion tensor using single-echo and multi-echo DTI pulse sequences. Simulations were also performed in models with histology-informed geometry to investigate the relationship between fiber size and the diffusion tensor in models with real muscle geometry. Fiber size is the strongest predictor of λ2, λ3, mean diffusivity, and fractional anisotropy in skeletal muscle, accounting for approximately 40% of the variance in the diffusion model when calculated with single-echo DTI. This increased to approximately 70% when diffusion measures were calculated from the short T2 component of the multi-echo DTI sequence. This nonlinear relationship begins to plateau in fibers with greater than 60-μm diameter. As the no...Continue Reading

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Citations

Oct 24, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jan N RoseDenis J Doorly
Jun 19, 2019·Physics in Medicine and Biology·Noel M Naughton, John G Georgiadis
May 19, 2018·The Journal of Orthopaedic and Sports Physical Therapy·David B BerrySamuel R Ward
Mar 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·Matthew F KoffDarryl B Sneag
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Aug 11, 2020·Biomaterials Science·David B BerrySamuel R Ward
Oct 16, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Noel M Naughton, John G Georgiadis
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Nov 24, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David B BerrySamuel R Ward
Mar 4, 2021·BMC Musculoskeletal Disorders·Xiaohong LyuShinong Pan
Mar 5, 2021·Frontiers in Neurology·Valentina MazzoliGarry E Gold
Jul 22, 2020·Journal of Neuroscience Methods·Ileana O JelescuKurt G Schilling
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Apr 6, 2021·Journal of Neuromuscular Diseases·Anne-Katrin GüttschesLara Schlaffke
May 8, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chu-Chung HuangDerek K Jones
Jun 29, 2021·Journal of Neuromuscular Diseases·R RehmannL Schlaffke
Aug 15, 2021·Journal of Magnetic Resonance Imaging : JMRI·Erin K EnglundEric E Sigmund

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