Relationships between tumour response and primary tumour location, and predictors of long-term survival, in patients with RAS wild-type metastatic colorectal cancer receiving first-line panitumumab therapy: retrospective analyses of the PRIME and PEAK clinical trials

British Journal of Cancer
M PeetersSalvatore Siena

Abstract

Data from two trials of panitumumab in metastatic colorectal cancer (mCRC) were retrospectively analysed to investigate the effects of primary tumour location on early-tumour shrinkage (ETS) and depth of response (DpR), and identify factors predicting long-term survival. Patients with RAS wild-type mCRC from PRIME (NCT00364013) and PEAK (NCT00819780) were included. ETS was defined as a ≥30% reduction in the sum-of-the-longest-diameters of measurable target lesions at eight weeks. DpR was the maximum percentage change from baseline to nadir in patients with shrinkage. Univariate and multivariate logistic analyses of short- versus long-term survivor data were performed. A total of 435/559 (78%) patients had left-sided disease. Of these, a higher proportion of patients treated with panitumumab versus comparator achieved ETS (PRIME: 62% vs. 36%; PEAK: 58% vs. 41%); median DpR was also higher with panitumumab (PRIME: 59% vs. 49%; PEAK: 70% vs. 48%). In pooled analyses of the studies, more patients with right-sided disease achieved ETS if treated with panitumumab than comparator (39% vs. 29%). Panitumumab treatment consistently predicted long-term survival. First-line panitumumab was associated with improved ETS and DpR vs. comparato...Continue Reading

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Citations

Dec 5, 2018·World Journal of Clinical Cases·Feng XuChao-Liu Dai
Nov 15, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Karen BolhuisCornelis J A Punt
Oct 2, 2019·Bulletin du cancer·Achille FabreMarine Jary
Jun 2, 2021·Journal of the National Cancer Institute·Jun YinHeinz-Josef Lenz

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Methods Mentioned

BETA
Subtyping
biopsy

Clinical Trials Mentioned

NCT00364013
NCT00819780
NCT03311750
NCT03227926
NCT03259009

Software Mentioned

PRIME
REPEAT
RASINTRO
CHRONOS
PEAK

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