Relationships of cervical lymph node metastasis to histopathological malignancy grade, tumor angiogenesis, and lymphatic invasion in tongue cancer.

Odontology
Yasuo Okada

Abstract

Cervical lymph node (CLN) metastasis from oral cancer correlates with poor prognosis. Therefore, accurate assessment of CLN status is crucial in treatment planning. However, there are few reports focusing on CLN metastasis from tongue cancer. Further, the growth and progress of the tumor are known to be profoundly related to histological malignancy, tumor angiogenesis, and lymphangiogenesis. Thus, this study aimed to identify predictive factors for CLN metastasis in tongue squamous cell carcinoma (SCC). Initial biopsy specimens obtained from 30 patients with tongue SCC were examined to evaluate histological malignancy according to Anneroth's classification. In addition, blood vessel density, lymph vessel density, and lymphatic invasion in the tumor were evaluated immunohistochemically using CD31, CD34, D2-40, and AE1/AE3, and then the relationships of CLN metastasis to these parameters were investigated. Histological malignancy grade, blood vessel density, and lymphatic invasion were significantly related to CLN metastasis (P < 0.05), but there was no relationship between lymph vessel density and CLN metastasis. However, double immunostaining showed that lymphatic invasion by tumor cells was significantly related to CLN metasta...Continue Reading

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Citations

Sep 23, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sandra B C TarquinioJacques E Nör
Apr 15, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yasuhisa ShinozakiNobuyuki Taniguchi
Sep 13, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Peer W KämmererJürgen Brieger
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Helenisa Helena Oliveira-NetoAline Carvalho Batista
Jan 13, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yoshiko ArijiEiichiro Ariji
Apr 26, 2017·Polish journal of radiology·Paulina PałaszMichał Studniarek
Aug 18, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Kazuya HaraguchiKazuhiro Tominaga

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