Relationships of Insulin Action to Age, Gender, Body Mass Index, and Waist Circumference Present Diversely in Different Glycemic Statuses among Chinese Population

Journal of Diabetes Research
Shao-Jie PangJian Zhang

Abstract

To study the influence of different glycemic statuses on the relationship of insulin action to age, gender, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) among Chinese population. A total of 35,327 participants (17,456 males and 17,871 females) were included in this nationally representative cross-sectional study. Glycemic status was defined according to the 2010 American Diabetes Association criteria. Fasting insulin was measured by the chemiluminescence method. Insulin and HOMA-IR levels were the highest in newly diagnosed diabetes and were lowest in normal fasting glucose (NFG) (P < 0.001). Insulin and HOMA-IR levels were higher in females (P < 0.001) than in males with previously diagnosed diabetes and impaired fasting glucose (IFG) and NFG, meanwhile decreased with age (P < 0.001) among IFG and NFG participants. As compared with participants with a BMI from 18.5 to 19.9, those in the lowest BMI category (<18.5) had a significantly elevated risk of IR (OR, 1.96; 95% CI, 1.01-3.80), as did those in the higher BMI categories among NFG participants. The risk of IR increased with WC and WHtR, and the response was linear (P < 0.001 for linear trend) for the participants with NFG but not in tho...Continue Reading

References

Oct 1, 1989·The American Journal of Clinical Nutrition·M A FlynnG Krause
Feb 1, 1985·Clinical Physiology·H Yki-JärvinenS L Karonen
Apr 1, 1995·Annals of Internal Medicine·G A ColditzJ E Manson
May 1, 1999·Reproduction, Nutrition, Development·J GrizardC Obled
Jun 12, 2004·American Journal of Epidemiology·Pauline Koh-BanerjeeEric B Rimm
Aug 17, 2004·The Medical Clinics of North America·Ralph A DeFronzo
Mar 10, 2005·The American Journal of Clinical Nutrition·Youfa WangFrank B Hu
Jan 19, 2007·The New England Journal of Medicine·Parvez HossainMeguid El Nahas
May 8, 2008·Cell Metabolism·Thien T TranC Ronald Kahn
Dec 3, 2008·Clinical Cornerstone·Sydney A Westphal
Mar 26, 2011·Diabetes & Metabolism·B Antuna-PuenteJ-P Bastard
Aug 10, 2011·Diabetes Research and Clinical Practice·Pilar Gayoso-DizAngel De Francisco
Nov 24, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M AshwellS Gibson
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
May 23, 2015·Diabetes Care·Luc Van Gaal, André Scheen
Jun 30, 2016·Diabetes & Metabolic Syndrome·Shalini Verma, M Ejaz Hussain
Dec 10, 2016·The Journal of Endocrinology·Liping Luo, Meilian Liu
May 28, 2017·Biomedical and Environmental Sciences : BES·Yi ZhaiWen Hua Zhao
Jun 6, 2017·International Journal of Epidemiology·UNKNOWN NCD Risk Factor Collaboration (NCD-RisC) – Africa Working Group
Jun 28, 2017·JAMA : the Journal of the American Medical Association·Limin WangLinhong Wang
Jul 12, 2017·Nature Medicine·Michael P Czech

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
J Ma, Lan Xiao
International Journal of Obesity : Journal of the International Association for the Study of Obesity
W AekplakornP Suriyawongpaisal
Diabetic Medicine : a Journal of the British Diabetic Association
V A DiazA Majeed
© 2022 Meta ULC. All rights reserved