Relationships of Microbiome Markers With Extraintestinal, Psychological Distress and Gastrointestinal Symptoms, and Quality of Life in Women With Irritable Bowel Syndrome.

Journal of Clinical Gastroenterology
Emily B HollisterMargaret M Heitkemper

Abstract

Altered microbial diversity has been associated with gastrointestinal (GI) symptoms in persons with irritable bowel syndrome (IBS). Less is known about the relationship of microbiome with extraintestinal pain and psychological distress symptoms and quality of life (QOL) in persons with IBS. We aimed to evaluate the relationship of fecal microbiota to GI symptoms, stool consistency, psychological distress, extraintestinal pain, and QOL in participants meeting Rome III criteria for IBS. Seventy-six women completed a 28-day diary that included GI, stool consistency, psychological distress, and extraintestinal pain ratings. Participants completed the IBS-Specific Quality of Life questionnaire. Stool samples were collected and analyzed by 16S rRNA gene sequencing. Principal component analysis was performed and the first 2 components (PC1, PC2) were used to test relationships among bacterial families and clinical measures. Participants were categorized as IBS constipation (n=22), IBS diarrhea (n=39), IBS mixed (n=13), and IBS unsubtyped (n=2). There was a significant group effect for the Firmicutes to Bacteroidetes ratio and PC1. Lower microbial diversity and richness were associated with increased urgency and extraintestinal pain, w...Continue Reading

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Citations

Aug 9, 2019·Research in Nursing & Health·Claire J HanMargaret M Heitkemper
Feb 13, 2020·Therapeutic Advances in Gastroenterology·William D CheyHerbert L DuPont
Sep 29, 2020·Frontiers in Endocrinology·Marloes Dekker NitertBarbora de Courten
Aug 9, 2020·Gastroenterology Research and Practice·Chang-Qing YangShu-Ting Sheng
Sep 30, 2020·Nursing Research·Katherine A MakiGwenyth R Wallen
Aug 15, 2021·European Journal of Clinical Investigation·Riccardo VasapolliPeter Malfertheiner
Oct 26, 2021·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Sarah W MatthewsKendra Kamp

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Methods Mentioned

BETA
Amplicon-Seq
contraception

Clinical Trials Mentioned

NCT00907790

Software Mentioned

SPSS Statistics
LOTUS
VSEARCH
bowtie2

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