Relationships of x-irradiation to the enhancement of Candida albicans infections.

Journal of Bacteriology
R S Gordee, P J Simpson

Abstract

Preirradiation significantly reduced the number of Candida albicans cells required for the ld(50) of experimentally infected mice. The start and extent of recovery of total leukocytes of preirradiated infected mice were proportional to the dose of X rays administered. During 10 days postinfection, heterophils of infected mice preirradiated with 400 R recovered to levels above unirradiated, uninfected controls but did not exceed those of unirradiated, infected animals. On the other hand, the more radiosensitive lymphocytes were depressed greatly, and a limited recovery below normal values was obtained. The lymph to heterophil ratio of uninfected mice irradiated with 400 R recovered to normal values by 11 days postirradiation. However, decreases in the ratio of unirradiated or X-irradiated infected mice showed little recovery. During 6 to 10 days postinfection, a reduction in microhematocrit values after a dose of 400 R alone was not observed when a C. albicans infection was superimposed on X-irradiated mice. This difference was not due to changes in the red blood cell volume which was decreased by 400 R with or without infection, but was attributed to a greater decrease in plasma volume caused by a combination of X irradiation a...Continue Reading

References

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Citations

Aug 7, 1981·Mycopathologia·M P WhitcombR W Weise
Oct 1, 1977·The Journal of Urology·K R McLeishR S Filo
Oct 1, 1989·Antimicrobial Agents and Chemotherapy·A Padula, H F Chambers
Jul 1, 1973·Antimicrobial Agents and Chemotherapy·J A LinquistI M Smith
Oct 1, 1970·Applied Microbiology·R S Gordee, T R Matthews

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