PMID: 9546258Apr 18, 1998Paper

Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of well-differentiated thyroid cancer

The Laryngoscope
M M MulcahyW Schmidt

Abstract

The need for and extent of thyroid surgery for a thyroid nodule is usually primarily based on fine-needle aspiration (FNA) and frozen section diagnosis. The relative role of these modalities in 66 patients who had undergone FNA and subsequent thyroidectomy with frozen section was investigated. Cases that demonstrated discordance between FNA and frozen section (n = 22; 33%) were identified, and all slides were re-reviewed by a cytopathologist using current established cytologic criteria. A change in diagnosis was made in 13 cases with an increase in accuracy of FNA from 71% to 88%. The accuracy of frozen section (92%) did not change appreciably with re-review (94%). The accuracy of FNA and frozen section combined was found to be 98%. The rate of discordance decreased from 33% to 13% with re-review. When strict histologic and cytologic criteria are applied, FNA and frozen section are accurate and complementary methods that help in determining the operative management of thyroid masses. However, when FNA yields a diagnosis of "follicular neoplasm," frozen section is unlikely to change this diagnosis.

Citations

Dec 22, 2004·Current Treatment Options in Oncology·Jyotika K FernandesAnand K Sharma
Dec 20, 2000·Current Surgery·L LloydI Audet
Mar 11, 2004·Thyroid : Official Journal of the American Thyroid Association·Rocco BellantoneGuido Fadda
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Matthew C MillerEdmund A Pribitkin
Mar 27, 2010·Surgery·Reza AsariBruno Niederle
Mar 13, 2001·American Journal of Clinical Pathology·E LeteurtreM Lecomte-Houcke
Jul 4, 2009·Brazilian Journal of Otorhinolaryngology·João Paulo Alves de AlmeidaRogério Aparecido Dedivitis
Aug 18, 2004·Pathology, Research and Practice·Jaron AssafJochanan H Boss
Aug 24, 2013·ANZ Journal of Surgery·Jia Bin BaiJulie A Miller
Feb 17, 2015·The Journal of Laryngology and Otology·F BegbieL J Clark
May 5, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D L MandellM L Urken
May 5, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J BrennanK J Shuler
Aug 9, 2001·International Journal of Surgical Pathology·Lisa A. Cerilli, Mark R. Wick
Mar 5, 2003·The Laryngoscope·Núria AlonsoAnna Sanmartí
Oct 11, 2017·Journal of Pathology and Translational Medicine·Agustina D Abelardo
Jul 15, 2000·Cancer Control : Journal of the Moffitt Cancer Center·C A Muro-Cacho, N N Ku
Dec 15, 2020·Surgical Oncology·Alvaro SanabriaAlfio Ferlito
Dec 7, 2005·Archives of Pathology & Laboratory Medicine·Rose C Anton, Thomas M Wheeler

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