Relative adrenal insufficiency in cirrhotic patients

Clinical Medicine Insights. Gastroenterology
Sotirios N AnastasiadisThemistoklis G Vasiliadis

Abstract

Relative adrenal insufficiency (RAI) was demonstrated in patients with cirrhosis and liver failure. A relationship appears to exist between the severity of the liver disease and the presence of RAI. Neither the mechanism nor the exact prevalence of RAI is fully understood. There is though a hypothesis that low high-density lipoprotein (HDL) levels in this group of patients may be responsible for the insufficiency of cortisol. Several questions also arise about the way and the kind of cortisol (total cortisol, free cortisol, or even salivary cortisol) that should be measured. The presence of RAI in patients with cirrhosis is unquestionable, but still several studies should come up in order to properly define it and fully understand it.

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Dec 14, 2016·AACN Advanced Critical Care·Diane McLaughlin, Lori Shellenback
Nov 18, 2015·World Journal of Gastroenterology : WJG·Sara Blasco-AlgoraConrado M Fernández-Rodríguez
May 25, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Brian J WentworthZachary H Henry

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