Relative analgesic potency of oral zomepirac and intramuscular morphine in cancer patients with postoperative pain

Journal of Clinical Pharmacology
S L WallensteinR W Houde

Abstract

A twin crossover assay of oral zomepirac and intramuscular morphine was completed in 159 cancer patients with postoperative pain. Zomepirac was a surprisingly effective oral analgesic in these patients, 100 mg orally being roughly equivalent to 16 mg intramuscular morphine. Time-effect data indicate that the peak effect for oral zomepirac may occur slightly later than that for morphine but that zomepirac is relatively rapidly effective after oral administration. Side effect occurrence was roughly in the same range for both drugs, with drowsiness, nausea, dry mouth, and feelings of weakness being observed after both drugs while sweating was observed more frequently after zomepirac. The assay further provided a demonstration of the effectiveness of the twin crossover design as a clinical assay method, providing increased sensitivity of crossover data in a patient population available for only a limited number of study treatments.

References

Apr 1, 1980·Journal of Clinical Pharmacology·T P PrussL D Muschek

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Citations

Jul 1, 1983·Canadian Anaesthetists' Society Journal·G L DunnA M Fargas-Babjak
Jul 7, 1988·European Journal of Pharmacology·N E RhalebR G Browne
Oct 1, 1985·The American Journal of the Medical Sciences·D E HainesR E Uphold
Nov 1, 1987·American Journal of Surgery·R C Hall
Nov 1, 1981·Journal of Clinical Pharmacology·J E Stambaugh, C Sarajian
Oct 1, 1980·British Journal of Clinical Pharmacology·S L WallensteinR W Houde
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·R W Houde
Aug 1, 1984·Journal of Clinical Pharmacology·R K DesirajuJ F Pritchard
Oct 1, 1984·Journal of Clinical Pharmacology·W Schady, H E Torebjörk
Apr 1, 1980·Journal of Clinical Pharmacology·W H Forrest
Oct 1, 1981·Journal of Clinical Pharmacology·S Honig, K A Murray
Feb 1, 1985·Annals of Emergency Medicine·R H Sandler
May 1, 1984·Oral Surgery, Oral Medicine, and Oral Pathology·S A CooperC Dyer
Jan 1, 1983·The Journal of the American Dental Association·H L CrossleyR L Wynn
Apr 23, 2016·The Cochrane Database of Systematic Reviews·Philip J WiffenR Andrew Moore
Jul 1, 1981·Drug Intelligence & Clinical Pharmacy·D C McLeod
May 15, 1984·Cancer·S L Wallenstein
Nov 1, 1983·Journal of Clinical Pharmacology·R J CapetolaJ L McGuire
Jan 14, 1983·Journal of Chromatography·J M GrindelN L Renzi

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