Relative and absolute risks of all-cause and cause-specific deaths attributable to atrial fibrillation in middle-aged and elderly community dwellers

International Journal of Cardiology
Masaki OhsawaAkira Okayama

Abstract

The relative and absolute risks of outcomes other than all-cause death (ACD) attributable to atrial fibrillation (AF) stratified age have not been sufficiently investigated. A prospective study of 23,634 community dwellers aged 40 years or older without organic cardiovascular disease (AF=335, non-AF=23,299) was conducted. Multivariate-adjusted rates, rate ratios (RRs) and excess deaths (EDs) for ACD, cardiovascular death (CVD) and non-cardiovascular death (non-CVD), and sex- and age-adjusted RR and ED in middle-aged (40 to 69) and elderly (70 years or older) for ACD, CVD, non-CVD, sudden cardiac death (SCD), stroke-related death (Str-D), neoplasm-related death (NPD), and infection-related death (IFD) attributable to AF were estimated using Poisson regression. Multivariate-adjusted analysis revealed that AF significantly increased the risk of ACD (RR [95% confidence interval]:1.70 [1.23-2.95]) and CVD (3.86 [2.38-6.27]), but not non-CVD. Age-stratified analysis revealed that AF increased the risk of Str-D in middle-aged (14.5 [4.77-44.3]) and elderly individuals (4.92 [1.91-12.7]), SCD in elderly individuals (3.21 [1.37-7.51]), and might increase the risk of IFD in elderly individuals (2.02 [0.80-4.65], p=0.098). The RR of CVD w...Continue Reading

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Sep 1, 1987·Archives of Internal Medicine·P A WolfW B Kannel
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·Y TanizakiM Fujishima
Aug 16, 2006·Expert Opinion on Drug Safety·Luke R BereznickiElla C Jeffrey
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Muneyoshi OgawaUNKNOWN Northern Iwate Heart Disease Registry Consortium
Aug 19, 2008·International Journal of Cardiology·Masaki OhsawaAkira Okayama
Nov 21, 2009·Journal of the American College of Cardiology·L Julian HaywoodUNKNOWN ALLHAT Collaborative Research Group
May 26, 2011·JAMA : the Journal of the American Medical Association·David ConenChristine M Albert
Mar 22, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Walter P WodchisDante Morra
Dec 12, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Thomas WilkeGünter Breithardt
Jan 29, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shinichi OmamaAkira Okayama
Feb 6, 2013·International Journal of Cardiology·Jocasta BallSimon Stewart
Feb 14, 2013·Circulation. Arrhythmia and Electrophysiology·Peter M OkinRichard B Devereux
May 4, 2013·Stroke; a Journal of Cerebral Circulation·Shinichi OmamaKiyomi Sakata

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