Relative antioxidant capacities of propofol and its main metabolites

Archives of Toxicology
Sandrine BoissetJérôme Guitton

Abstract

The antioxidant activity of propofol, a widely used anesthetic, has previously been demonstrated, but no study has focused on propofol metabolites although propofol undergoes extensive metabolism. In the present study, the antioxidant properties of propofol and its metabolites were studied by measuring malondialdehyde (MDA) produced from lipid peroxidation by microsomes triggered with several free radical generating systems. True MDA determination was performed using a specific high performance liquid chromatography technique. Gas chromatography-isotope ratio mass spectrometry methodology was also used to assess the antioxidant action in a homogeneous aqueous environment. Propofol, 2,6-di-isopropyl-1,4-quinol (1,4-quinol) metabolite and 3,5-di- tert-butyl-4-hydroxytoluene markedly inhibit lipid peroxidation at concentrations lower than 5 microM. The binding of the glucuroconjugated moiety to either one of two hydroxyl groups of 1,4-quinol lowers the radical scavenging activity. Propofol glucuronide did not exert any radical scavenging activity except when peroxidation was induced with tert-butylhydroperoxide. Our data demonstrate that propofol and its metabolites inhibit lipid peroxidation at concentrations similar to those mea...Continue Reading

References

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Citations

Jun 24, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Monika BhadauriaSangeeta Shukla
Mar 17, 2010·Cell Biochemistry and Function·Fusun ErogluMustafa Naziroğlu
Feb 24, 2006·Clinical Biochemistry·Remziye SivaciOsman Nuri Dilek
Feb 12, 2013·Redox Report : Communications in Free Radical Research·Ivana BudicTatjana Jevtovic-Stoimenov
Aug 18, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Sónia P CamposLuís M Antunes
Oct 20, 2020·Arhiv za higijenu rada i toksikologiju·Sandra Alavuk KundovićKsenija Črnjar
Nov 10, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hironori TsuchiyaMaki Mizogami

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