Abstract
In homeopathy, it is claimed that more homeopathically-diluted potencies render more protective/curative effects against any disease condition. Potentized forms of Condurango are used successfully to treat digestive problems, as well as esophageal and stomach cancers. However, the comparative efficacies of Condurango 6C and 30C, one diluted below and one above Avogadro's limit (lacking original drug molecule), respectively, have not been critically analyzed for their cell-killing (apoptosis) efficacy against lung cancer cells in vitro, and signalling cascades have not been studied. Hence, the present study was undertaken. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide (MTT) assays were conducted on H460-non-small-cell lung cancer (NSCLC) cells by using a succussed ethyl alcohol vehicle (placebo) as a control. Studies on cellular morphology, cell cycle regulation, generation of reactive oxygen species (ROS), changes in mitochondrial membrane potential (MMP), and DNA-damage were made, and expressions of related signaling markers were studied. The observations were done in a "blinded" manner. Both Condurango 6C and 30C induced apoptosis via cell cycle arrest at subG0/G1 and altered expressions of certain apoptotic m...Continue Reading
References
Dec 16, 1983·Journal of Immunological Methods·T Mosmann
Jul 13, 2000·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·W B Jonas
Jan 23, 2002·Cell Death and Differentiation·M F DenningJ-Z Qin
Jun 25, 2003·The Journal of Biological Chemistry·Yi-He LingRoman Perez-Soler
Nov 19, 2003·Molecular and Cellular Biochemistry·Anisur Rahman Khuda-Bukhsh
Nov 15, 2006·Integrative Cancer Therapies·Anisur R Khuda-Bukhsh
Nov 15, 2006·Integrative Cancer Therapies·Wayne B JonasRadha K Maheshwari
Nov 23, 2007·Journal of Cell Science·Yongqiang ChenSpencer B Gibson
Mar 4, 2008·Methods : a Companion to Methods in Enzymology·Zbigniew DarzynkiewiczHong Zhao
Jun 9, 2009·BMC Cancer·Yanyan WangXingfu Song
Dec 24, 2009·BMC Cancer·Jorge Morales, Mary L Alpaugh
Mar 31, 2010·Journal of Agricultural and Food Chemistry·Bin-Chuan JiJing-Gung Chung
Apr 13, 2010·Carcinogenesis·Kristian DreijDavid A Scicchitano
Jun 1, 2010·Experimental Biology and Medicine·Soumya Sundar BhattacharyyaAnisur Rahman Khuda-Bukhsh
Oct 26, 2010·Homeopathy : the Journal of the Faculty of Homeopathy·Prashant Satish ChikramaneShantaram Govind Kane
Apr 8, 2011·Journal of Ethnopharmacology·Hsia-Fen HsuJer-Yiing Houng
Oct 23, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Prashant S ChikramaneJayesh R Bellare
Oct 24, 2012·BMC Complementary and Alternative Medicine·Iris R Bell, Mary Koithan
Sep 1, 2013·Journal of Pharmacopuncture·Sourav SikdarAnisur Rahman Khuda-Bukhsh
Citations
Jun 23, 2015·International Journal of Oncology·Shilpi SahaTanya Das
Nov 13, 2015·Journal of Integrative Medicine·Santu Kumar SahaAnisur Rahman Khuda-Bukhsh
Aug 1, 2019·International Journal of Oncology·Jenifer Pendiuk GonçalvesCarolina Camargo De Oliveira
Dec 7, 2016·Microscopy Research and Technique·Lartiza F LimaJosé Ricardo Figueiredo
Dec 22, 2020·Homeopathy : the Journal of the Faculty of Homeopathy·Andreza Pereira Dos SantosLeoni Villano Bonamin