Relative bioavailability of folate from the traditional food plant Moringa oleifera L. as evaluated in a rat model

Journal of Food Science and Technology
R K SainiP Giridhar

Abstract

Moringa oleifera is an affordable and rich source of dietary folate. Quantification of folate by HPLC showed that 5-formyl-5,6,7,8-tetrahydrofolic acid (502.1 μg/100 g DW) and 5,6,7,8-tetrahydrofolic acid (223.9 μg/100 g DW) as the most dominant forms of folate in M. oleifera leaves. The bioavailability of folate and the effects of folate depletion and repletion on biochemical and molecular markers of folate status were investigated in Wistar rats. Folate deficiency was induced by keeping the animals on a folate deficient diet with 1 % succinyl sulfathiazole (w/w). After the depletion period, animals were repleted with different levels of folic acid and M. oleifera leaves as a source of folate. Feeding the animals on a folate deficient diet for 7 weeks caused a significant (3.4-fold) decrease in serum folate content, compared to non-depleted control animals. Relative bioavailability of folate from dehydrated leaves of M. oleifera was 81.9 %. During folate depletion and repletion, no significant changes in liver glycine N-methyl transferase and 5-methyltetrahydrofolate-homocysteine methyltransferase expression were recorded. In RDA calculations, only 50 % of natural folate is assumed to be bioavailable. Therefore, the bioavailab...Continue Reading

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Citations

Nov 10, 2017·PloS One·Diriba B KumssaMartin R Broadley
Jul 22, 2019·Animals : an Open Access Journal From MDPI·Shad Mahfuz, Xiang Shu Piao
Oct 1, 2019·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·R S Drisya RaviBindu R Nair
Nov 17, 2019·Plants·Thulani TshabalalaAshwell Rungano Ndhlala
Sep 18, 2021·Journal of Food Biochemistry·Shalini Arora, Saurabh Arora

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