Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet

European Journal of Clinical Nutrition
Kirstine S KrogholmSalka E Rasmussen

Abstract

The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated. Ten healthy men were asked to consume a 'juice mix' containing equal amounts of the three flavonoids, and their urine and plasma samples were collected. The resulting mean plasma area under the curve (AUC)(0-48 h) and C(max) values for quercetin and hesperetin were similar, whereas the AUC(0-48 h) of naringenin and, thus, the relative bioavailability were higher after consumption of the same dose. The study consolidates a significantly lower urinary excretion of quercetin (1.5+/-1%) compared with hesperetin (14.2+/-9.1%) and naringenin (22.6+/-11.5%) and shows that this is not due to a lower bioavailability of quercetin, but rather reflects different clearance mechanisms.

References

Jan 11, 2005·The American Journal of Clinical Nutrition·Claudine ManachChristian Rémésy
Dec 5, 2008·Journal of Agricultural and Food Chemistry·William MullenAlan Crozier

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Citations

May 29, 2015·Molecular Nutrition & Food Research·Lucas Actis-GorettaGary Williamson
Apr 16, 2016·World Journal of Clinical Oncology·Guilherme di Camillo OrfaliDenise Gonçalves Priolli
Apr 10, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Carina KolotWilhelm Stahl
Oct 28, 2019·Critical Reviews in Food Science and Nutrition·Iveta NajmanováPřemysl Mladěnka
Nov 21, 2020·Molecular Nutrition & Food Research·Theresa SaengerHans-Ulrich Humpf
May 1, 2018·Comprehensive Reviews in Food Science and Food Safety·A Filipa AlmeidaCláudia N Santos
Oct 23, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Mirza BojićMaja Tomičić

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