Abstract
To determine the relative biologic effects (RBE) of alpha-particle radiation from 227Th-rituximab and of beta-radiation from 90Y-tiuexetan-ibritumomab (Zevalin) compared with external beam X-radiation in the Raji lymphoma xenograft model. Radioimmunoconjugates were administered intravenously in nude mice with Raji lymphoma xenografts at different levels of activity. Absorbed dose to tumor was estimated by separate biodistribution experiments for 227Th-rituximab and Zevalin. Tumor growth was measured two to three times per week after injection or X-radiation. Treatment-induced increase in growth delay to reach tumor volumes of 500 and 1,000 mm3, respectively, was used as an end point. The absorbed radiation dose-rate in tumor was slightly more than 0.1 Gy/d for the first week following injection of 227Th-rituximab, and thereafter gradually decreased to 0.03 Gy/d at 21 days after injection. For treatment with Zevalin the maximum dose-rate in tumor was achieved already 6 h after injection (0.2 Gy/d), and thereafter decreased to 0.01 Gy/d after 7 days. The relative biologic effect was between 2.5 and 7.2 for 227Th-rituximab and between 1 and 1.3 for Zevalin. Both at low doses and low-dose-rates, the 227Th-rituximab treatment was mo...Continue Reading
References
Nov 1, 1994·International Journal of Radiation Biology·G W Barendsen
Jan 12, 2000·Archives of Disease in Childhood·D Hall
Oct 25, 2002·Cancer Biotherapy & Radiopharmaceuticals·Thomas M BehrGeorge Sgouros
Jul 8, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Katia VandenbulckeGuido Slegers
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sten NilssonOyvind S Bruland
May 31, 2007·Blood·Jostein DahleRoy H Larsen
Jun 5, 2007·The Lancet Oncology·Sten NilssonOyvind S Bruland
Citations
Jul 14, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Jostein DahleRoy H Larsen
Dec 7, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Young-Seung Kim, Martin W Brechbiel
Jun 19, 2012·Physics in Medicine and Biology·Robert F HobbsGeorge Sgouros
Jan 5, 2012·EJNMMI Research·Nasir AbbasJostein Dahle
Aug 11, 2012·PloS One·Helen HeyerdahlJostein Dahle
May 13, 2014·Immunotherapy·Christof Seidl
Nov 17, 2015·Drug Development and Industrial Pharmacy·Janne Olsen FrenvikOlav B Ryan
Feb 27, 2016·International Journal of Radiation Biology·Chandan KumarBadri N Pandey
Apr 2, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Scott N PenfoldEva Bezak
Sep 16, 2016·Drug Development and Industrial Pharmacy·Janne Olsen FrenvikOlav B Ryan
Apr 13, 2017·Drug Development and Industrial Pharmacy·Janne Olsen FrenvikOlav B Ryan
Jan 23, 2020·Cancer Biotherapy & Radiopharmaceuticals·Viviana FrantellizziGiuseppe De Vincentis
Jun 20, 2020·Cancer Biotherapy & Radiopharmaceuticals·Francisco D C Guerra LiberalKevin M Prise
Sep 6, 2014·Nuclear Medicine Communications·Alexander H StaudacherMichael P Brown
Dec 1, 2020·Frontiers in Oncology·Maria Luisa BelliGiovanni Paganelli
Feb 10, 2021·Nuclear Medicine and Biology·Jasmine L Hatcher-LamarreLynn C Francesconi
Apr 4, 2021·Annals of Nuclear Medicine·Chul-Hee LeeSang Moo Lim
Oct 1, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tom BäckStig Palm
Mar 3, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sophie PotyJason S Lewis