Relative biological effectiveness of fast neutrons in a multiorgan assay for apoptosis in mouse

Environmental Toxicology
Hae-June LeeSung-Ho Kim

Abstract

This study compared the effects of high linear energy transfer (LET) fast neutrons on the induction of apoptosis in several tissue types (hair follicle, intestine crypt, testis) of ICR mouse exposed to low LET 60Co gamma-rays. The changes that occurred from 0 to 24 h after exposing the mice to either 2 Gy of gamma-rays (2 Gy/min) or 0.8 Gy of neutrons (94 mGy/min, 35 MeV) were examined. The maximum frequency of apoptosis was observed at 8 or 12 h after irradiation. The mice that had received 0-8 Gy of gamma-rays or 0-1.6 Gy of neutrons were examined 8 h after irradiation. The best-fitting dose-response curves were linear-quadratic, and there was a significant relationship between the number of apoptotic cells and the dose. The stained products in the TUNEL-positive cells or bodies correlated with the typical morphologic characteristics of apoptosis observed by optical microscopy. In the follicles showing an apoptosis frequency between 2 and 14 per hair follicle, the relative biological effectiveness (RBE) of the neutrons in the small and large follicles was 2.09 +/- 0.31 and 2.15 +/- 0.18, respectively. In the intestine crypts showing an apoptosis frequency between 1 and 3 per crypt, the RBE of the neutrons was 4.03 +/- 0.06 an...Continue Reading

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Citations

May 16, 2013·BMC Complementary and Alternative Medicine·Tae Gen SonJoong Sun Kim
Dec 14, 2011·Phytotherapy Research : PTR·Joong-Sun KimSung-Ho Kim
Dec 5, 2009·Phytotherapy Research : PTR·Changjong MoonTaekyun Shin
Aug 10, 2011·International Journal of Radiation Biology·Richard P HillAnna Treadway Heinink
May 1, 2015·The World Journal of Men's Health·Wan LeeJoong Sun Kim
Feb 16, 2021·Radiation Research·Daniela L StricklinLanyn P Taliaferro

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis