Relative cerebral blood volume is a potential predictive imaging biomarker of bevacizumab efficacy in recurrent glioblastoma

Neuro-oncology
Philipp KickingerederAlexander Radbruch

Abstract

To analyze the relevance of dynamic susceptibility-weighted contrast-enhanced MRI (DSC-MRI) derived relative cerebral blood volume (rCBV) analysis for predicting response to bevacizumab (BEV) in patients with recurrent glioblastoma (rGB). A total of 127 patients diagnosed with rGB receiving either bevacizumab (71 patients, BEV cohort) or alkylating chemotherapy (56 patients, non-BEV cohort) underwent conventional anatomic MRI and DSC-MRI at baseline and at first follow-up after treatment initiation. The mean rCBV of the contrast-enhancing tumor (cT1) as well as cT1 and fluid-attenuated inversion recovery (FLAIR) volumes at both time points were correlated with progression-free survival (PFS) and overall survival (OS) using Cox proportional hazard models, logistic regression, and the log-rank test. Baseline rCBV was associated with both PFS (hazard ratio [HR] = 1.3; P < .01) and OS (HR = 1.3; P < .01) in the BEV cohort and predicted 6-month PFS in 82% and 12-month OS in 79% of patients, whereas it was not associated with PFS (HR = 1.0; P = .70) or OS (HR = 1.0; P = .47) in the non-BEV cohort. Corresponding median OS and PFS rates in the BEV cohort for patients with rCBV-values less than 3.92 (optimal threshold from receiver oper...Continue Reading

References

Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L OstergaardB R Rosen
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ona WuA Gregory Sorensen
Feb 3, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kim MouridsenLeif Ostergaard
Jul 24, 2007·Nature Reviews. Neuroscience·Rakesh K JainTracy T Batchelor
May 22, 2008·Journal of the National Comprehensive Cancer Network : JNCCN·Eric T Wong, Steven Brem
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry S FriedmanTimothy Cloughesy
Jan 13, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J J C VerhoeffD J Richel
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Apr 20, 2010·International Journal of Radiation Oncology, Biology, Physics·Victor A LevinEdward F Jackson
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olivier KeunenSimone P Niclou
Feb 27, 2014·CNS Oncology·Kevin LeuBenjamin M Ellingson

❮ Previous
Next ❯

Citations

Feb 3, 2016·Critical Reviews in Oncology/hematology·Katharina SeystahlMichael Weller
Jul 30, 2015·Clinical Neuroradiology·A Radbruch, M Bendszus
Apr 26, 2015·Neuro-oncology·Whitney B Pope
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·Jerrold L BoxermanWhitney B Pope
Feb 11, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David BonekampPhilipp Kickingereder
Mar 30, 2017·International Journal of Molecular Sciences·Michael C BurgerOliver Bähr
Nov 22, 2017·International Journal of Molecular Sciences·Michael C BurgerJoachim P Steinbach
Aug 18, 2018·The Cancer Journal·Michelle M KimDenise Leung
Oct 10, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Junjie WuDeqiang Qiu
Oct 18, 2016·Current Opinion in Oncology·Antonella Castellano, Andrea Falini
Mar 17, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R A Manneh KoppA Hernández-Laín
Mar 5, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Cornelius DeuschlMarc Schlamann
Sep 2, 2017·Expert Review of Neurotherapeutics·Norbert GalldiksKarl-Josef Langen
Nov 3, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Philipp KickingerederDavid Bonekamp
Jan 21, 2021·Neuro-oncology·Adam A Dmytriw, Raymond Y Huang
Jun 10, 2020·Neuro-oncology·Jerrold L BoxermanUNKNOWN Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee
Oct 30, 2020·Cancer Management and Research·Houyi KangWeiguo Zhang
Nov 30, 2020·Drug Discovery Today·Rebecca KassubekHeiko G Niessen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.