Relative changes in cerebral blood flow and neuronal activity in local microdomains during generalized seizures

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Hrachya NersesyanHal Blumenfeld

Abstract

There is broad agreement that generalized tonic-clonic seizures (GTCS) and normal somatosensory stimulation are associated with increases in regional CBF. However, the data regarding CBF changes during absence seizures are controversial. Electrophysiologic studies in WAG/Rij rats, an established animal model of absence seizures, have shown spike-wave discharges (SWD) that are largest in the perioral somatosensory cortex while sparing the visual cortex. Recent functional magnetic resonance imaging (fMRI) studies in the same model have also shown localized increases in fMRI signals in the perioral somatosensory cortex during SWD. Because fMRI signals are only indirectly related to neuronal activity, the authors directly measured CBF and neuronal activity from specific microdomains of the WAG/Rij cortex using a specially designed probe combining laser-Doppler flowmetry and extra-cellular microelectrode recordings under fentanyl/haloperidol anesthesia. Using this approach, parallel increases in neuronal activity and CBF were observed during SWD in the whisker somatosensory (barrel) cortex, whereas the visual cortex showed no significant changes. For comparison, these measurements were repeated during somatosensory (whisker) stimula...Continue Reading

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Citations

Jan 31, 2004·Epilepsy & Behavior : E&B·Kelly A McNally, Hal Blumenfeld
Apr 3, 2009·Brain : a Journal of Neurology·G I VargheseH Blumenfeld
Dec 8, 2007·Cerebral Cortex·Ulrich SchriddeHal Blumenfeld
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Sep 9, 2005·Epilepsia·Kelly A McNallyHal Blumenfeld
Feb 14, 2007·Epilepsia·Miro EnevHal Blumenfeld
Oct 6, 2007·Epilepsia·Hal Blumenfeld
Jul 9, 2010·Epilepsia·Rachel BermanHal Blumenfeld
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Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mingrui ZhaoTheodore H Schwartz
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May 18, 2018·Nature Communications·Jochen MeyerStelios Smirnakis

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