PMID: 3651779Aug 1, 1987

Relative contribution of bile and pancreatic juice duodenogastric reflux in gastric ulcer disease and cholelithiasis

The British Journal of Surgery
I A Eyre-BrookA G Johnson

Abstract

Bile acid concentrations, phospholipase A2 activity and pH in the stomach were measured in the fasting state and for 2 h after a fat-containing test meal in patients with an active gastric ulcer (GU), in patients with gallstones before and after cholecystectomy and in normal subjects. Fasting and peak postprandial bile acid concentrations in the stomach were low in all normal controls. Although high concentrations were found in many patients with GU (P less than 0.01), similar concentrations were found in many patients with radiologically non-functioning gallbladders containing gallstones (NFG) (P less than 0.01) and also after cholecystectomy (AC) (P less than 0.01). Fasting intragastric phospholipase A2 activities were similar, and very high in GU and NFG patients compared with control subjects (P less than 0.01). High values were not found after cholecystectomy. There was no difference in pH profile or in postprandial phospholipase A2 between patient groups. Since patients with cholelithiasis or after cholecystectomy are not known to have an increased incidence of gastric ulceration, the significance of duodenogastric reflux in the aetiology of gastric ulcers must be questioned. If reflux does produce ulcers in GU patients t...Continue Reading

References

Jan 1, 1977·Scandinavian Journal of Gastroenterology·M RokkjaerJ B Petersen
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Jun 1, 1972·The British Journal of Surgery·A G Johnson
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Aug 1, 1983·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·I A Eyre-BrookA G Johnson
Nov 1, 1980·Digestive Diseases and Sciences·L J MillerV L Go
Nov 10, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·N C Bird

Citations

Jun 1, 1991·Zentralblatt für Veterinärmedizin. Reihe A·U BraunF Ehrensperger
Dec 1, 1991·Scandinavian Journal of Gastroenterology·J KellosaloS Laitinen
Feb 1, 1990·Scandinavian Journal of Gastroenterology·B ErikssonS Emås
Jul 30, 2016·Scientific Reports·Ming-Chieh TsaiCha-Ze Lee
Jan 14, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniel Mønsted ShabanzadehTorben Jørgensen

Related Concepts

Bile Salts
Cholelithiasis
Duodenogastric Reflux
Gastric Acidity Determination
Phospholipase
Phospholipases A
Stomach
Gastric Ulcer
Phospholipases A2

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Related Papers

Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics
I A Eyre-BrookA G Johnson
Clinica Chimica Acta; International Journal of Clinical Chemistry
N C Bird
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