PMID: 3651779Aug 1, 1987

Relative contribution of bile and pancreatic juice duodenogastric reflux in gastric ulcer disease and cholelithiasis

The British Journal of Surgery
I A Eyre-BrookA G Johnson


Bile acid concentrations, phospholipase A2 activity and pH in the stomach were measured in the fasting state and for 2 h after a fat-containing test meal in patients with an active gastric ulcer (GU), in patients with gallstones before and after cholecystectomy and in normal subjects. Fasting and peak postprandial bile acid concentrations in the stomach were low in all normal controls. Although high concentrations were found in many patients with GU (P less than 0.01), similar concentrations were found in many patients with radiologically non-functioning gallbladders containing gallstones (NFG) (P less than 0.01) and also after cholecystectomy (AC) (P less than 0.01). Fasting intragastric phospholipase A2 activities were similar, and very high in GU and NFG patients compared with control subjects (P less than 0.01). High values were not found after cholecystectomy. There was no difference in pH profile or in postprandial phospholipase A2 between patient groups. Since patients with cholelithiasis or after cholecystectomy are not known to have an increased incidence of gastric ulceration, the significance of duodenogastric reflux in the aetiology of gastric ulcers must be questioned. If reflux does produce ulcers in GU patients t...Continue Reading


Jan 1, 1977·Scandinavian Journal of Gastroenterology·M RokkjaerJ B Petersen
Jan 1, 1976·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·E KivilaaksoM Lempinen
Feb 1, 1975·The American Journal of Physiology·W Silen, J G Forte
Apr 1, 1986·The British Journal of Surgery·V PoxonM R Keighley
Feb 25, 1967·Lancet·W M CapperM J Gibson
Oct 1, 1970·Journal of Clinical Pathology·G M MurphyD N Baron
Sep 1, 1974·Gut·A G Johnson, S J McDermott
Jun 1, 1973·The American Journal of Digestive Diseases·J R MalageladaW S Gamble
Jul 1, 1973·Gut·J B Cocking, P Grech
Jun 1, 1972·The British Journal of Surgery·A G Johnson
Apr 1, 1972·Gut·K G Wormsley
Feb 21, 1970·British Medical Journal·M A Hassan, M Hobsley
Sep 1, 1970·Gut·F J Flint, P Grech
Aug 1, 1983·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·I A Eyre-BrookA G Johnson
Nov 1, 1980·Digestive Diseases and Sciences·L J MillerV L Go
Nov 10, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·N C Bird


Jun 1, 1991·Zentralblatt für Veterinärmedizin. Reihe A·U BraunF Ehrensperger
Dec 1, 1991·Scandinavian Journal of Gastroenterology·J KellosaloS Laitinen
Feb 1, 1990·Scandinavian Journal of Gastroenterology·B ErikssonS Emås
Jul 30, 2016·Scientific Reports·Ming-Chieh TsaiCha-Ze Lee
Jan 14, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniel Mønsted ShabanzadehTorben Jørgensen

Related Concepts

Bile Salts
Duodenogastric Reflux
Gastric Acidity Determination
Phospholipases A
Gastric Ulcer
Phospholipases A2

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics
I A Eyre-BrookA G Johnson
Clinica Chimica Acta; International Journal of Clinical Chemistry
N C Bird
© 2021 Meta ULC. All rights reserved