PMID: 7333998Dec 1, 1981Paper

Relative contributions of sulfur atoms of dietary cysteine and methionine to rat liver glutathione and proteins

Journal of Biochemistry
N TateishiY Sakamoto

Abstract

The relative contributions of sulfur atoms of dietary L-Cys and L-Met to the syntheses of proteins and GSH in rat liver were examined. 1) When the amount of sulfur-containing amino acids in L-Trp-deficient diets was fixed at 0.36%, incorporation of L-[35S]Cys into GSH was proportional to the amount of L-Cys administered, in the presence of L-Met in the diet. Incorporation of 35S from L-Met into GSH was lower than that from the same amount of L-Cys and became negligible in the presence of a large amount of L-Cys. 2) When rats were given L-Trp-deficient diet, more L-Cys was always incorporated into liver GSH than into proteins. But, when rats were given L-Trp-fortified diet containing more L-Met than L-Cys, more L-Cys was incorporated into liver proteins than into GSH. 3) Met-sulfur was preferentially incorporated into liver proteins with or without L-Trp. Its absolute incorporation into proteins was significantly greater in the presence of L-Trp than in its absence. 4) When the amount of L-Met in the diet was increased from 0.18 to 0.36 or 0.54%, incorporation of Met-sulfur into proteins increased proportionally, in the presence of 0.18% L-Cys. Unexpectedly, incorporation of L-Cys formed from L-Met into liver proteins was larger...Continue Reading

Citations

Sep 30, 2005·Addiction Biology·M Luisa Murillo-FuentesOlimpia Carreras
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·M J Hamadeh, L J Hoffer
Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B H LauterburgJ R Mitchell
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·M J HamadehL J Hoffer
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Antonio FranciosoMario Fontana
Jan 1, 1988·Pharmacology & Therapeutics·M Reicks, J N Hathcock
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D M Latta, W E Donaldson
Aug 1, 1983·The Journal of Investigative Dermatology·M MojamdarY Mishima
Sep 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·N SaravananP Varalakshmi
Sep 22, 2007·Journal of Agricultural and Food Chemistry·Shigeru Katayama, Yoshinori Mine
Aug 28, 2010·Nutrition Research·Jana StrakovaTimothy A Garrow

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