Relative disutilities of 47 risk factors and conditions assessed with seven preference-based health status measures in a national U.S. sample: toward consistency in cost-effectiveness analyses

Medical Care
Peter FranksD G Fryback

Abstract

Preference-based health measures yield summary scores that are compatible with cost-effectiveness analyses. There is limited comparative information, however, about how different measures weight health conditions in the U.S. population. We examined data from 11,421 adults in the 2000 Medical Expenditure Panel Survey, a nationally representative sample of the U.S. general population, using information on sociodemographics (age, gender, race/ethnicity, income, and education), health status (EQ-5D, EQ-VAS, and SF-12), 4 risk factors (smoking, overweight, obesity, and lacking health insurance), and 43 conditions. From the EQ-5D, we derived summary scores using U.K. [EQ(UK)] and U.S. weights. From the SF-12 we derived SF-6D, and regression-predicted EQ-5D (U.S. and U.K. weights) and Health Utility Index scores. Each of the 7 preference measures was regressed on each of the 47 problems (risk factors and conditions) to determine the disutility associated with the problem, adjusting for socio-demographics. The adjusted disutilities averaged across the 47 problems for the 7 preference measures ranged from 0.059 for the SF-6D to 0.104 for the EQ(UK). Correlations between each of the measures of the adjusted disutilities ranged from 0.85-...Continue Reading

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