PMID: 37295May 1, 1979

Relative effects of different surfactants on intestinal absorption and the release of proteins and phospholipids from the tissue

The Journal of Pharmacy and Pharmacology
D A WhitmoreK P Wheeler

Abstract

The actions of anionic, cationic and non-ionic surfactants on the absorptive capability of rat jejunal tissue in vivo were compared with their effects on the amounts of protein and phospholipid released from the mucosal surface under the same conditions. Release of a comparatively small amount of protein was accompanied by large increases in the absorption rates of both L-valine and salicylate, whereas much larger quantities of phospholipid were released before any increase in absorption were observed. Much of the released material appeared to be derived from mucus which was partly degraded after exposure to the higher concentrations of surfactants. The liberation of cholesterol by high concentrations of anionic surfactants suggested that some disruption of the mucosal membrane occurred under those conditions. The relative potency of the surfactants in stimulating both absorption of the solutes and the release of polypeptides and lipids followed the order: anionic greater than non-ionic greater than cationic. The possible pharmaceutical relevance of these findings is discussed.

References

Mar 1, 1975·The Journal of Pharmacy and Pharmacology·A T Florence, J M Gillan
Dec 1, 1977·Journal of Pharmaceutical Sciences·L S Wan
Oct 1, 1976·Journal of Pharmaceutical Sciences·S Feldman, M Reinhard
Jul 1, 1969·Analytical Biochemistry·R M ZachariusJ J Woodlock

Citations

Mar 1, 1986·Veterinary Research Communications·J B Kaneene, R W Ross
Dec 28, 2007·Pharmaceutical Research·Yogeeta NarkarJoseph R Robinson
Jan 1, 1989·Pharmacology & Therapeutics·E J van HoogdalemD D Breimer
Apr 1, 1995·Journal of Pharmacological and Toxicological Methods·R L OberleD A Krummel
Oct 27, 1999·Biomaterials·F Edwards-Lévy, M C Lévy
Apr 14, 2012·Journal of Pharmaceutical Sciences·In Koo ChunHye Sun Gwak
Apr 29, 1983·Pharmaceutisch Weekblad. Scientific Edition·J H Jonkman, C A Hunt
Apr 1, 1981·The Journal of Pharmacy and Pharmacology·K A WaltersA T Florence
Jan 1, 1980·The Journal of Pharmacy and Pharmacology·D A WhitmoreK P Wheeler
Dec 1, 1981·The Journal of Pharmacy and Pharmacology·G P Martin, C Marriott

Related Concepts

Thin Layer Chromatography
SDS-PAGE
Intestinal Absorption
Phospholipids
Salicylic Acids
Tensides
Valine

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