PMID: 8977599Oct 1, 1996Paper

Relative effects of inhaled corticosteroids on immunopathology and physiology in asthma: a controlled study

Thorax
C BurkeL W Poulter

Abstract

Although corticosteroids are recognised as the most efficacious treatment for bronchial asthma, their mode of action remains unclear. A placebo controlled trial was undertaken of the effect of inhaled corticosteroids on physiological and immmunopathological parameters in asthmatic patients in whom the correlations between these indices were tested after treatment. Sixteen patients (two women) with asthma entered a double blind, placebo controlled, parallel study during which they inhaled either budesonide 800 micrograms twice daily or matching placebo for six weeks. Spirometric parameters and bronchial reactivity to histamine and terbutaline were measured and endobronchial biopsy samples were taken before and after treatment. Patients recorded morning and evening flow rates during the treatment period. The biopsy samples were subjected to immunohistological analysis to determine the disposition of inflammatory cells within the bronchial wall. Treatment with budesonide resulted in a significant improvement in the 25-75% forced expiratory flow (FEF25-75) from a mean of 133 l/min before treatment to 169 l/min after treatment, and in the morning peak expiratory flow rate (PEFR) from a mean of 384 l/min before treatment to 415 l/min...Continue Reading

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Citations

Oct 2, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V J TormeyL W Poulter
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L CormicanL W Poulter
Dec 22, 1999·Clinical and Experimental Immunology·V J TormeyL W Poulter
Jun 2, 1998·American Journal of Respiratory and Critical Care Medicine·L M FabbriA Ciaccia
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·J L FaulL W Poulter
May 22, 2013·Pulmonary Pharmacology & Therapeutics·Lucia SpicuzzaRiccardo Polosa
Dec 14, 2002·American Journal of Respiratory and Critical Care Medicine·Siobhán O'SullivanLeonard W Poulter
Jun 18, 2002·Chest·Edward MoloneyConor M Burke
Oct 1, 1996·Immunobiology·L W Poulter, C M Burke
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S E OverbeekJ-B Prins
Sep 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jill R JohnsonManel Jordana
Nov 1, 2001·The Cochrane Database of Systematic Reviews·N AdamsP W Jones
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D K C LeeB J Lipworth
Sep 8, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bryan G BelikoffDaniel G Remick

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