Relative effects of prolactin excess and estrogen deficiency on bone in rats

Metabolism: Clinical and Experimental
R A AdlerR J Krieg

Abstract

Humans with prolactinoma are at risk for osteoporosis. The relative contributions of hyperprolactinemia-induced hypogonadism and the prolactin (PRL) excess per se have been unclear from clinical studies. To determine the effects of PRL excess, two models of chronic hyperprolactinemia were used. In one, mild hyperprolactinemia was produced in rats bearing extra anterior pituitary glands under the kidney capsule. Severe hyperprolactinemia was produced by subcutaneously transplanting the PRL-secreting MMQ tumor into other rats. To control for estrogen deficiency, the rats were ovariectomized. In some experiments, estrogen replacement was provided. Urinary calcium excretion was increased in hyperprolactinemic rats compared with controls, regardless of severity of PRL excess and estrogen status. This suggested that PRL excess itself had some effect on calcium balance. More importantly, however, the spinal bone mineral density (BMD; measured by dual-energy x-ray densitometry) of mildly hyperprolactinemic ovariectomized rats was the same as control ovariectomized rats. Similarly, tibial dry weight and ash weight were affected by the estrogen status, but not by the severe PRL excess of the tumor-implanted rats. Thus, despite the eviden...Continue Reading

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Citations

Jan 22, 2011·Psychiatry Investigation·Tae-Young LeeHyung-Seok So
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Tatiana ManciniAndrea Giustina
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·D CossA M Walker
Jan 12, 2005·Journal of Clinical Psychopharmacology·Veronica O'Keane, Anna Maria Meaney
Aug 17, 2010·Regulatory Toxicology and Pharmacology : RTP·Takeshi KunimatsuTakaki Seki

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