Relative efficacy of different immunization schedules for the prevention of serogroup C meningococcal disease: a model-based evaluation

Vaccine
Philippe De WalsJacques Pépin

Abstract

Different immunization strategies have been implemented for the control of serogroup C meningococcal disease (CMD) in Canada and in other developed countries. Results from effectiveness studies of conjugate vaccines in the UK and Spain indicate waning immunity over time. To estimate the life-time protection conferred by different immunization schedules, a simulation model was constructed based on the current epidemiologic situation in Canada. Results showed that the efficacy of any immunization schedule was highly influenced by the rate at which immunity waned and that the benefit of a booster dose increased with increasing rates of waning immunity. Schedules including several doses in early infancy provided little additional benefit over programs starting with 1 dose at the age of 12 months. One-dose programs provided low levels of protection, unless the vaccine was administered at the age of 12 months, and a waning immunity rate of 1% per year or less was assumed. The most effective schedule was 5 doses given at age 2 months, 4 months, 1 year, 12 years, and 18 years, but was only marginally better than 2 doses provided at 12 months and 12 years of age. Existing routine immunization schedules may not be optimal and should be d...Continue Reading

Citations

Apr 22, 2010·Neurological Research·Marco Aurélio Palazzi Sáfadi, Otávio Augusto Leite Cintra
Nov 10, 2009·Bulletin of Mathematical Biology·Konstantin B Blyuss, Yuliya N Kyrychko
Dec 11, 2014·Expert Review of Vaccines·Marco Aurélio SáfadiUNKNOWN Global Meningococcal Initiative
Sep 23, 2006·Expert Review of Vaccines·Harry L KeyserlingGregory P Gilmet
Jun 23, 2009·Expert Review of Vaccines·Caroline L Trotter, Martin C J Maiden
Dec 28, 2007·Vaccine·Africa González-FernándezCarmen Fernández
Jan 5, 2014·Human Vaccines & Immunotherapeutics·Maria Grazia PascucciMaria Pia Fantini
May 16, 2013·Vaccine·Eva-Maria PoellabauerHartmut J Ehrlich
Dec 23, 2006·Expert Review of Vaccines·Ray Borrow, Elizabeth Miller
Jun 3, 2009·Expert Review of Vaccines·Stephen I Pelton, Gregory P Gilmet
Mar 3, 2009·Expert Review of Vaccines·Ray Borrow, Jamie Findlow
Oct 19, 2016·The Pediatric Infectious Disease Journal·Julie A BettingerJoenel Alcantara
Jan 26, 2010·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada

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