Nov 24, 1983

Relative fitness can decrease in evolving asexual populations of S. cerevisiae

C E Paquin, Julian Adams


It is generally accepted from the darwinian theory of evolution that a progressive increase in population adaptation will occur in populations containing genetic variation in fitness, until a stable equilibrium is reached and/or the additive genetic variation is exhausted. However, the theoretical literature of population genetics documents exceptions where mean population fitness may decrease in response to evolutionary changes in gene frequency, due to varying selective coefficients, sexual selection or to epistatic interactions between loci. Until now, no examples of such exceptions have been documented from fitness estimates in either natural or experimental populations. We present here direct evidence that, as a result of epistatic interactions between adaptive mutations, mean population fitness can decrease in asexual evolving populations of the yeast Saccharomyces cerevisiae.

  • References74
  • Citations6


  • References74
  • Citations6

Mentioned in this Paper

Reproduction, Asexual
Saccharomyces cerevisiae allergenic extract
Theory of Evolution
Haploid Cell
Deviation, Epistatic
Diploid Cell
Saccharomyces cerevisiae
Biological Evolution
Variation (Genetics)

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