Relative frequency and risk factors for long-term opioid therapy following surgery and trauma among adults: a systematic review protocol

Systematic Reviews
M Gabrielle PagéHance Clarke

Abstract

When patients have been on opioid therapy for more than 90 days, more than half of them continue using opioids years later. Knowing that long-term opioid consumption could lead to harmful side effects including misuse, abuse, and addiction, it is important to understand the risks of transitioning to prolonged opioid therapy to reduce its occurrence. Perioperative and trauma contexts are ideal models commonly used to study such transition. Long-term use of opioids might be associated with transformation of acute pain to chronic, which might be an example of a risk factor. The objectives of this knowledge synthesis are to examine the relative frequency and the risk factors for transitioning to long-term opioid therapy among patients who have undergone a surgical procedure or experienced a trauma. The proposed study methodology is based on Preferred ReportIng Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) statements on the conduct of systematic review and meta-analysis, the MOOSE Guidelines for Meta-Analyses and Systematic Reviews of Observational Studies, and the Cochrane Handbook for Systematic Review of Interventions. A systematic literature search will include multiple databases: Cochrane Central, EMBASE, MEDLINE, P...Continue Reading

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Citations

Feb 2, 2021·Neuropharmacology·Arbi NazarianThomas J Martin
Jul 20, 2021·The Journal of Surgical Research·Kathleen E SingerAmy T Makley
Aug 23, 2021·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Jeanette FinstadIngrid Amalia Havnes
Dec 26, 2021·Journal of Orthopaedic Surgery and Research·Amy L XuCasey J Humbyrd

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Software Mentioned

PRISMA Flowchart
Review Manager
DistillerSR
Google scholar
EMTREE
EPHPP
EndNote
EPOC Risk of Bias Tool Quality Assessment Tool for
Pro Quest
MOOSE

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