Relative hyperhomocysteinemia in patients with panic disorder: a case-control study

Neuropsychobiology
Christian MeierFranziska Geiser

Abstract

The aim of this work was to examine a possible association between a clinically relevant panic disorder and plasma total homocysteine concentration. 23 patients with panic disorder with or without agoraphobia confirmed by a standardized clinical interview (Structural Clinical Interview for DSM-IV-German version) and 23 healthy controls matched for gender and age completed questionnaires (SCL-K9, STAI, ADS, STAXI) and had blood drawn after a 15 min rest. Plasma total homocysteine concentrations were measured by competitive enzyme immunoassay. Interfering variables such as age, gender, smoking status, comorbid depression and medication were controlled for. Patients with panic disorder had higher plasma homocysteine concentrations in comparison to the control group (mean value 11.00 vs. 9.14 mumol/l, p = 0.04 with age, gender, smoking status, comorbid depression and antidepressant medication being controlled for). Furthermore, homocysteine plasma concentration was positively correlated with Global Severity of Symptoms (SCL-K9, r(Pearson) = 0.41, p < 0.01). The findings of this study suggest a link between elevated plasma homocysteine levels and panic disorder. This raises a new hypothesis of another pathway to an increased risk of...Continue Reading

Citations

Nov 30, 2011·International Journal of Psychiatry in Clinical Practice·Hande YapislarÜnal Ozüm
Mar 25, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Domenico De BerardisMassimo Di Giannantonio
Sep 25, 2020·Brain and Behavior·Seyed Shahrokh AghayanMoslem Jafarisani

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