Relative importance of abnormalities of CCK and 5-HT (serotonin) in Giardia-induced post-infectious irritable bowel syndrome and functional dyspepsia

Alimentary Pharmacology & Therapeutics
V DizdarTrygve Hausken

Abstract

Post-infectious irritable bowel syndrome (PI-IBS) and functional dyspepsia (FD) have been described after both Campylobacter jejuni gastroenteritis and Giardia infection. After C. jejuni, there is increased rectal serotonin (5-HT)-containing EC cells and postprandial plasma 5-HT, while a pilot study suggested increased plasma cholecystokinin (CCK) after Giardia infection. To determine changes in plasma and duodenal mucosal 5-HT and CCK in Giardia-induced PI-IBS. A total of 32 patients previously infected with Giardia and 19 who had recovered fully (controls) completed symptom questionnaires. Endoscopic duodenal biopsies were obtained from all subjects and immunohistochemically stained for CCK, 5-HT and CgA containing entero-endocrine cells and mast cells. 5-HT content was also assessed. Twenty-one of 32 patients and 19 controls consumed a high-carbohydrate meal, while fasting and postprandial plasma CCK and 5-HIAA were measured. Post-infectious irritable bowel syndrome patients had increased numbers of CCK cells (P = 0.02), but lower numbers of EC cells (P = 0.009). Plasma CCK did not differ significantly between the groups, but correlated significantly with postprandial dyspepsia scores (r = 0.5, P = 0.05). PI-IBS patients had...Continue Reading

Citations

Mar 8, 2014·World Journal of Gastroenterology : WJG·Magdy El-SalhyTrygve Hausken
Mar 1, 2012·International Journal of Molecular Medicine·M El-SalhyT Hausken
Apr 20, 2014·World Journal of Gastroenterology : WJG·Jennifer K BeattyAndre G Buret
Jun 19, 2014·International Journal of Molecular Medicine·Magdy El-SalhyTrygve Hausken
Dec 10, 2013·Regulatory Peptides·Magdy El-SalhyTrygve Hausken
Dec 5, 2015·Frontiers in Cellular Neuroscience·Marie C M Halliez, André G Buret
May 10, 2011·Regulatory Peptides·Konstantinos Kalafatakis, Konstantinos Triantafyllou
Mar 16, 2017·ACS Chemical Neuroscience·Md Sharif ShajibWaliul I Khan
Apr 30, 2017·Gut and Liver·Nicholas J Talley
Jun 4, 2014·World Journal of Gastrointestinal Endoscopy·Magdy El-SalhyTrygve Hausken
Jul 4, 2018·Journal of Neurogastroenterology and Motility·Hirokazu FukuiHiroto Miwa
Jul 15, 2015·World Journal of Gastroenterology : WJG·Magdy El-Salhy
May 5, 2020·The Proceedings of the Nutrition Society·Benjamin CrooksJohn T McLaughlin
May 12, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Cristina MartínezBeate Niesler
Oct 16, 2012·World Journal of Gastroenterology : WJG·Magdy El-Salhy
Nov 3, 2015·World Journal of Gastroenterology : WJG·Hisashi IizasaHironori Yoshiyama
Dec 31, 2014·World Journal of Gastroenterology : WJG·Cynthia K Y Cheung, Justin C Y Wu
Sep 4, 2015·World Journal of Gastroenterology : WJG·Magdy El-SalhyTrygve Hausken
Apr 25, 2020·World Journal of Gastroenterology : WJG·Vanessa D'AntongiovanniNunzia Bernardini
Jan 30, 2021·Frontiers in Microbiology·Elena FeketeAndre G Buret

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