PMID: 2503631May 1, 1989Paper

Relative importance of amino acid infusion as a means of sparing protein in surgical patients

JPEN. Journal of Parenteral and Enteral Nutrition
D A HumberstoneJ H Shaw

Abstract

We performed isotopic infusions in 51 surgical patients to investigate the effectiveness of different substrates to conserve protein. All patients were initially studied in the basal state and then the effects of glucose infusion (GL, N = 13), lipid infusion (LIP, N = 11), or amino acid infusion (AA, N = 17) were determined. Ten patients receiving total parenteral nutrition (TPN) were also studied. The basal value for net protein catabolism (NPC) in GL patients was 1.53 +/- 0.4 (SEM) g/kg/day decreasing to 1.39 +/- 0.4 g/kg/day during glucose infusion (p less than 0.01). The basal NPC in the LIP group was 2.04 +/- 0.4 g/kg/day decreasing to 1.72 +/- 0.3 g/kg/day during lipid infusion (p less than 0.01). In the TPN patients the NPC was 0.79 +/- 0.46 g/kg/day whereas in the AA patients the basal value for NPC was 1.37 +/- 0.14 g/kg/day decreasing to -0.77 +/- 0.11 g/kg/day during amino acid infusion (p less than 0.0005). From our study we conclude that: (1) All substrates commonly used in intravenous feeding have the capacity to spare protein. (2) Protein sparing was more pronounced when a balanced amino acid infusion was used than with either glucose or lipid infusion alone. (3) This effect is not solely due to insulin secretion...Continue Reading

References

Feb 1, 1979·Archives of Surgery·J L MullenE F Rosato
Nov 1, 1979·JPEN. Journal of Parenteral and Enteral Nutrition·M M HickeyR L Yost
Mar 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·R R WolfeJ H Shaw
Apr 1, 1973·American Journal of Surgery·G L BlackburnT E O'Donnell
Mar 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·M J DaltonD M Kirking
Sep 25, 1959·Annals of the New York Academy of Sciences·R STEELE

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Citations

Jul 10, 2007·Metabolism: Clinical and Experimental·Thomas SchrickerFranco Carli
Oct 3, 1999·Journal of Pediatric Surgery·V B MarínF Q Barrera
Jan 1, 1996·JPEN. Journal of Parenteral and Enteral Nutrition·S Klein, J Miles
Jan 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·A L Peters, M B Davidson
Mar 1, 1996·The Journal of Trauma·C L LongW S Blakemore
Nov 24, 2006·Anesthesia and Analgesia·Francesco DonatelliFranco Carli
Jan 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·Z Kolacinski

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