Relative importance of quantifying area and vascular patterns in uveal melanomas

American Journal of Ophthalmology
M G MehaffeyK C Moore

Abstract

To test whether the cross-sectional area of choroidal and ciliary body melanomas and quantification of microcirculatory networks and parallel vessels with cross-linking are features associated with death from metastatic melanoma, and to compare new with conventional histologic prognostic features. The cross-sectional area of 234 ciliary body or choroidal melanomas was measured from digitized images of histologic sections. The percentage of cross-sectional area occupied by two microcirculatory patterns-networks and parallel vessels with cross-linking-was calculated for the 152 tumors containing at least one focus of either pattern. Kaplan-Meier survival curves were generated based on cross-sectional and percentage of cross-sectional areas of these patterns. Cox proportional hazard regression methods related time to death from melanoma with sets of predictor variables. For each model, percent variation explained was computed. Patient survival differs significantly when tumors are classified based on cross-sectional area: small (<16 mm2), medium (> or =16 mm2 but <61.4 mm2), and large (> or =61.4 mm2). Patients with tumors containing networks and parallel vessels with cross-linking microcirculation patterns that occupy 2% of cross...Continue Reading

References

Jan 1, 1977·Archives of Ophthalmology·M J McLeanL E Zimmerman
Jan 1, 1977·Archives of Ophthalmology·H F Shammas, F C Blodi
Nov 1, 1977·Archives of Ophthalmology·H F Shammas, F C Blodi
Jan 1, 1997·Ultrasound in Medicine & Biology·R H SilvermanD J Coleman

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Citations

Feb 10, 2000·The American Journal of Pathology·R FolbergA J Maniotis
Feb 10, 2000·The American Journal of Pathology·D M McDonaldR K Jain
Jul 25, 2003·Ultrasound in Medicine & Biology·Ronald H SilvermanD Jackson Coleman
Mar 2, 1999·Journal of the National Cancer Institute·T MäkitieT Kivelä
Dec 5, 2017·Journal of Ophthalmology·Juan J ToledoAlejandro López-Gaona
Nov 26, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Robert Folberg, Andrew J Maniotis
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·M C Kincaid

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