PMID: 9445006Jan 28, 1998Paper

Relative importance of rotavirus-specific effector and memory B cells in protection against challenge

Journal of Virology
C A MoserP A Offit

Abstract

Adult BALB/c mice were orally inoculated with murine (strain EDIM), simian (strain RRV), or bovine (strain WC3) rotavirus. Six or 16 weeks after inoculation, mice were challenged with EDIM. At the time of challenge and in the days immediately following challenge, production of rotavirus-specific immunoglobulin A (IgA), IgG, and IgM by small intestinal lamina propria lymphocytes (LPL) was determined by fragment culture, and quantities of virus-specific antibodies at the intestinal mucosal surface were determined by intestinal lavage. Mice immunized with EDIM were completely protected against EDIM challenge both 6 and 16 weeks after immunization. Protection was associated with production of high levels of IgA by LPL and detection of virus-specific IgA at the intestinal mucosal surface. In addition, animals immunized and later challenged with EDIM did not develop a boost in antibody responses, suggesting that they were also not reinfected. We also found that in mice immunized with nonmurine rotaviruses, (i) quantities of virus-specific IgA generated following challenge were greater 16 weeks than 6 weeks after immunization, (ii) immunization enhanced the magnitude but did not hasten the onset of production of high quantities of vir...Continue Reading

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Citations

Aug 21, 2002·Journal of Virology·Barbara S CoulsonMargo C Honeyman
Jan 12, 2005·Clinical and Diagnostic Laboratory Immunology·Janine ValoskySusan E Coffin
Nov 30, 2000·Current Infectious Disease Reports·S E Coffin
Dec 22, 2017·Viral Immunology·Paul A Offit
Oct 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wanqiang LiKangcheng Pan

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