Relative incidence and individual-level severity of seasonal influenza A H3N2 compared with 2009 pandemic H1N1

BMC Infectious Diseases
Kin On KwokBenjamin J Cowling

Abstract

Two subtypes of influenza A currently circulate in humans: seasonal H3N2 (sH3N2, emerged in 1968) and pandemic H1N1 (pH1N1, emerged in 2009). While the epidemiological characteristics of the initial wave of pH1N1 have been studied in detail, less is known about its infection dynamics during subsequent waves or its severity relative to sH3N2. Even prior to 2009, few data was available to estimate the risk of severe outcomes following infection with one circulating influenza strain relative to another. We analyzed antibodies in quadruples of sera from individuals in Hong Kong collected between July 2009 and December 2011, a period that included three distinct influenza virus epidemics. We estimated infection incidence using these assay data and then estimated rates of severe outcomes per infection using population-wide clinical data. Cumulative incidence of infection was high among children in the first epidemic of pH1N1. There was a change towards the older age group in the age distribution of infections for pH1N1 from the first to the second epidemic, with the age distribution of the second epidemic of pH1N1 more similar to that of sH3N2. We found no serological evidence that individuals were infected in both waves of pH1N1. Th...Continue Reading

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Citations

Jan 13, 2018·Future Microbiology·Lucy K SomervilleJen Kok
Jun 7, 2019·Influenza and Other Respiratory Viruses·Barbara RathUNKNOWN PEDSIDEA Network
Jun 4, 2020·Journal of Clinical Medicine·Eunha ShimGerardo Chowell
Oct 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cheryl CohenStefano Tempia
Jan 22, 2020·Emerging Infectious Diseases·Concepción Delgado-SanzAmparo Larrauri
Sep 21, 2018·Viruses·Frank T WenSarah Cobey
Feb 7, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Krystal LauKatharina Hauck

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