Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization

Journal of Vascular and Interventional Radiology : JVIR
Ryan M KieferTerence P F Gade

Abstract

To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access. One hundred thirty-eight male Wistar rats ingested 0.01% DEN in water ad libitum for 12 weeks. T2-weighted magnetic resonance imaging was used for tumor surveillance. Rats underwent selective embolization of ≥ 5 mm tumors via carotid or femoral artery catheterization under fluoroscopic guidance. Rats were retrospectively categorized into 3 groups by initial weight (< 300, 300-400, > 400 g) for analyses of survival, tumor latency, and fibrosis. Access site was compared relative to procedural success, mortality, and time. No significant differences in tumor latency were related to weight group (P = .310). Rats weighing < 300 g had shorter survival than both heavier groups (mean, 88 vs 108 d; P < .0001), and more severe fibrosis (< 300 g median, 4.0; 300-400 g median, 1.5; > 400 g median, 1.0; P = .015). No significant difference was found in periprocedural mortality based on access site; however, procedure times were shorter via femoral approach ...Continue Reading

Citations

Sep 26, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicholas R PerkonsTerence P F Gade
Nov 5, 2020·Metallomics : Integrated Biometal Science·Caroline I DavisDonita C Brady
Jun 6, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicholas R PerkonsTerence P F Gade
Aug 23, 2020·Journal of Vascular and Interventional Radiology : JVIR·Brian J ParkTerence P Gade
Nov 21, 2021·Journal of Vascular and Interventional Radiology : JVIR·Michal Mauda-HavakukWilliam F Pritchard

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